{"id":"W4210269483","doi":"10.1186/s12967-022-03242-9","title":"Polygenic risk and causal inference of psychiatric comorbidity in inflammatory bowel disease among patients with European ancestry","year":2022,"lang":"en","type":"article","venue":"Journal of Translational Medicine","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Manitoba; CancerCare Manitoba; Public Health Ontario; University of Toronto","funders":"Canadian Institutes of Health Research; Mitacs; Health Sciences Centre Foundation","keywords":"Genome-wide association study; Medicine; Inflammatory bowel disease; Odds ratio; Genetic association; Comorbidity; Population; Internal medicine; Disease; Genetics; Single-nucleotide polymorphism; Gene; Biology; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003738662,0.0006035023,0.0005581585,0.001399346,0.0005259818,0.0009292261,0.0005699603,0.0005535284,0.002504202],"category_scores_gemma":[0.01348932,0.0003038655,0.001479025,0.00167469,0.0004846407,0.0003167569,0.0009450088,0.0006543779,0.0001636344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002852505,"about_ca_system_score_gemma":0.0005167003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01671577,"about_ca_topic_score_gemma":0.01162603,"domain_scores_codex":[0.9974644,0.001611337,0.0001645997,0.0004770086,0.0001522124,0.0001304758],"domain_scores_gemma":[0.993193,0.004152993,0.001355166,0.0007320129,0.0003094348,0.0002573678],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001951648,0.00002031638,0.9950333,0.00001426469,0.0005431171,0.0001244818,0.00004879358,0.0008746101,0.0002506877,0.0001321267,0.0000737208,0.002689529],"study_design_scores_gemma":[0.00004673313,0.00007682824,0.9802223,0.00003153102,0.0007121423,0.0003775946,0.0001144796,0.01710967,0.0001902301,0.0008642493,0.000243064,0.00001122097],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949008,0.0005259301,0.003490913,0.0002160108,0.00001185691,0.00001301218,0.000377042,0.00002928042,0.0004351768],"genre_scores_gemma":[0.998741,0.00008163122,0.000886017,0.00002517249,0.000009850808,0.000005539817,0.0001872237,0.000002842682,0.00006088156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01671577,"threshold_uncertainty_score":0.03323692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01060194365719219,"score_gpt":0.2542685273168069,"score_spread":0.2436665836596147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}