{"id":"W4210277591","doi":"10.1158/1078-0432.ccr-21-2572","title":"Somatic and Germline Genomic Alterations in Very Young Women with Breast Cancer","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"Susan G. Komen; Breast Cancer Research Foundation","keywords":"Somatic cell; Germline; Breast cancer; Gene; Germline mutation; Young adult","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001995104,0.0001235488,0.0002097997,0.0005278878,0.0002169466,0.0002320375,0.0001032545,0.0002167424,0.0009516013],"category_scores_gemma":[0.0008667396,0.0001150107,0.0001505111,0.0004913684,0.0001788926,0.0001308735,0.0002274312,0.00011692,0.0001530938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001223565,"about_ca_system_score_gemma":0.0001498597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001212254,"about_ca_topic_score_gemma":0.002159099,"domain_scores_codex":[0.9998704,0.00002174184,0.00001519668,0.00004184404,0.00002501524,0.00002583546],"domain_scores_gemma":[0.9995422,0.0001047557,0.0002277492,0.00002167441,0.00002641807,0.0000771675],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001314517,0.000009850572,0.9964366,0.00001102155,0.00001637307,0.0003128877,0.0000383585,0.00002115075,0.001388478,0.000007083114,0.00004003362,0.001586688],"study_design_scores_gemma":[0.000004714377,0.00008426818,0.9980068,0.000003484435,0.00001460993,0.001423949,0.0000672347,0.00003167334,0.0002244179,0.00001416295,0.0001232268,0.000001450654],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993667,0.0002774062,0.00005263228,0.000006756376,0.000001881589,0.000003871684,0.0001709484,0.000001696981,0.0001180797],"genre_scores_gemma":[0.9994566,0.000120043,0.00008098801,0.00001521609,0.000004599292,0.000005173195,0.000257794,9.80746e-7,0.00005866442],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001212254,"threshold_uncertainty_score":0.003183365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06363039054810755,"score_gpt":0.4321887607606135,"score_spread":0.3685583702125059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}