{"id":"W4210277591","doi":"10.1158/1078-0432.ccr-21-2572","title":"Somatic and Germline Genomic Alterations in Very Young Women with Breast Cancer","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre","funders":"Susan G. Komen; Breast Cancer Research Foundation","keywords":"Somatic cell; Germline; Breast cancer; Gene; Germline mutation; Young adult","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008274403,0.0001196474,0.0002176215,0.00007744609,0.0003113006,0.00002841211,0.000179507,0.00004913052,0.000310061],"category_scores_gemma":[0.00003917419,0.0001024223,0.00002998161,0.0002402419,0.0002997775,0.000005912624,0.0004811395,0.0003782541,0.000003134568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003298032,"about_ca_system_score_gemma":0.0005181824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001599692,"about_ca_topic_score_gemma":0.003411694,"domain_scores_codex":[0.9981959,0.0003219415,0.0002769961,0.0004817232,0.0002864386,0.0004370372],"domain_scores_gemma":[0.9993531,0.00009443702,0.00005023031,0.0002774181,0.0001066276,0.0001181971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003312251,0.000445775,0.9690892,0.00005898851,0.0003130219,0.00003531378,0.0007920161,0.0005612342,0.007019093,0.0000257985,0.002027611,0.01631967],"study_design_scores_gemma":[0.002343096,0.0004734972,0.9921288,0.00002952658,0.00001534698,0.00003575894,0.0008119131,0.00007942868,0.0001910887,0.00009329284,0.003619963,0.0001782966],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936185,0.00284391,0.000004900604,0.002700343,0.0001229097,0.0002945112,0.0002573053,0.000006990197,0.0001505614],"genre_scores_gemma":[0.9944922,0.002172985,0.00003870026,0.0002526635,0.0003594067,0.002150307,0.00002787958,0.00002539159,0.0004805213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02303956,"threshold_uncertainty_score":0.417666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06363039054810755,"score_gpt":0.4321887607606135,"score_spread":0.3685583702125059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}