{"id":"W4210278550","doi":"10.1007/978-981-15-9411-3_48","title":"ROS-Mediated Apoptosis in Cancer","year":2022,"lang":"en","type":"book-chapter","venue":"","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Reactive oxygen species; Nicotinamide adenine dinucleotide phosphate; Oxidative stress; NADPH oxidase; Chemistry; Apoptosis; Mitochondrion; Cell biology; Superoxide dismutase; Mitochondrial ROS; Catalase; Cancer cell; Oxidative phosphorylation; Biochemistry; Biology; Cancer; Oxidase test; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001622777,0.0005837938,0.0004710529,0.0009291635,0.0004429182,0.001430378,0.0008034138,0.0008054782,0.01914313],"category_scores_gemma":[0.0001466572,0.000217396,0.0002638831,0.001254866,0.0003830803,0.00125224,0.0007258305,0.001520589,0.008578008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007954498,"about_ca_system_score_gemma":0.000512788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001013082,"about_ca_topic_score_gemma":0.002541115,"domain_scores_codex":[0.9999168,0.000009136957,0.000003132448,0.00001047478,0.00005183137,0.000008601191],"domain_scores_gemma":[0.9999602,0.00001609426,0.000002505498,0.000003600839,0.00001235418,0.000005207628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006168177,0.0001062808,0.00006287099,0.001109708,0.00001373925,0.000197411,0.0002614231,0.0006957226,0.01263316,0.1182934,0.2924819,0.5740827],"study_design_scores_gemma":[0.000003159415,0.00001682885,0.00007531643,0.0001329356,0.00000389943,0.0001842458,0.00003160008,0.0001072353,0.001116915,0.0119243,0.9864,0.000003367648],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001346159,0.6626058,0.006236399,0.004683115,0.006223536,0.00007225434,0.0002544296,0.0001768597,0.3184014],"genre_scores_gemma":[0.006970669,0.3369058,0.002569622,0.001515317,0.001629444,0.00007339419,0.0002030367,0.00005978713,0.6500729],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01914313,"threshold_uncertainty_score":0.06404018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01490860705956593,"score_gpt":0.2636607123640507,"score_spread":0.2487521053044848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}