{"id":"W4210278557","doi":"10.1002/cbic.202200061","title":"Synthetic Neoglycoconjugates of Hepta‐ and Nonamannoside Ligands for Eliciting Oligomannose‐Specific HIV‐1‐Neutralizing Antibodies","year":2022,"lang":"en","type":"article","venue":"ChemBioChem","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Anomer; Glycan; Chemistry; Epitope; Antibody; Glycosylation; Conjugate; Immunoglobulin Fab Fragments; Stereochemistry; Fragment crystallizable region; Biochemistry; Combinatorial chemistry; Glycoprotein; Peptide sequence; Biology; Complementarity determining region; Receptor; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001375,0.0003398487,0.000131137,0.0001587604,0.00008962804,0.0001957116,0.0001809085,0.0001766365,0.0007130074],"category_scores_gemma":[0.0001196153,0.0001459643,0.0001406984,0.0001519662,0.000116392,0.0001448975,0.0002374602,0.0003602125,0.0003943192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003046557,"about_ca_system_score_gemma":0.0002229803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000345267,"about_ca_topic_score_gemma":0.0007763666,"domain_scores_codex":[0.9998989,0.000026971,0.000006882084,0.00001140779,0.00003308688,0.00002263152],"domain_scores_gemma":[0.9999348,0.000009370141,0.00001876563,0.000008548112,0.00001005465,0.00001861202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002901158,0.00001516407,0.00006011207,0.00001449175,0.000002548367,0.00002545971,0.000008092315,0.0002696943,0.9981787,0.0001706966,0.0000159262,0.001210071],"study_design_scores_gemma":[0.000007266142,0.0001327466,0.0003691423,0.00000222367,0.000004635705,0.00005868416,0.000005639106,0.000585708,0.997493,0.00002531793,0.001313072,0.000002583263],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886464,0.0003710068,0.008274294,0.00004834663,0.00001852622,0.00007176261,0.0001531739,0.00004940863,0.002367186],"genre_scores_gemma":[0.9841729,0.0004789433,0.01200963,0.00007085202,0.000009971361,0.00006862238,0.0002999913,0.00003132275,0.002857767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007130074,"threshold_uncertainty_score":0.002385318,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01501282155950596,"score_gpt":0.2242375871543187,"score_spread":0.2092247655948128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}