{"id":"W4210280340","doi":"10.1002/jbmr.4524","title":"Differentiation of Induced Pluripotent Stem Cells Into Chondrocytes: Methods and Applications for Disease Modeling and Drug Discovery","year":2020,"lang":"en","type":"review","venue":"Journal of Bone and Mineral Research","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Medical Research Council; Universiteit Antwerpen; Medical Research Council Canada; Fonds Wetenschappelijk Onderzoek; National Marfan Foundation","keywords":"Induced pluripotent stem cell; Chondrocyte; Drug discovery; Cartilage; Disease; Stem cell; Neuroscience; Medicine; Human Induced Pluripotent Stem Cells; Computational biology; Bioinformatics; Biology; Cell biology; Pathology; Embryonic stem cell; Anatomy; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008910515,0.0007902334,0.0009806658,0.00271354,0.0001954297,0.000847248,0.0006432545,0.0008028712,0.002571724],"category_scores_gemma":[0.0006036323,0.0002769159,0.0005338294,0.001982881,0.0004821924,0.0008583622,0.0007147082,0.001846445,0.001938014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004425949,"about_ca_system_score_gemma":0.0006855662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006405364,"about_ca_topic_score_gemma":0.001062559,"domain_scores_codex":[0.9996744,0.00004187856,0.00004315353,0.00004484608,0.00017503,0.00002061053],"domain_scores_gemma":[0.9996461,0.0001744998,0.00004288236,0.00001652723,0.00009649001,0.00002347576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003411259,0.0000585682,0.0001422642,0.01192368,0.00006077598,0.0001523201,0.00005642277,0.0004408382,0.01144965,0.005497649,0.008890171,0.9612935],"study_design_scores_gemma":[0.00001674596,0.0001306889,0.0007745193,0.002589562,0.0001329234,0.001000957,0.00005083597,0.0002409006,0.007289191,0.003226364,0.9845145,0.00003285085],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002523731,0.9967299,0.001102836,0.0001935121,0.0001611694,0.00001747962,0.000047421,0.00001732017,0.001478059],"genre_scores_gemma":[0.001123837,0.9971048,0.0008586174,0.0001088595,0.00008179939,0.00001557256,0.00007240605,0.00000285224,0.0006312527],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00271354,"threshold_uncertainty_score":0.008603275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1217122679621657,"score_gpt":0.4377495982475473,"score_spread":0.3160373302853816,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}