{"id":"W4210288638","doi":"10.3390/vaccines10020196","title":"Neoantigen Cancer Vaccines: Generation, Optimization, and Therapeutic Targeting Strategies","year":2022,"lang":"en","type":"review","venue":"Vaccines","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Clinical trial; Therapeutic modalities; Cancer; Identification (biology); Cancer immunotherapy; Immunotherapy; Modalities; Computational biology; Immunology; Immune system; Biology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005141246,0.0007624647,0.001104461,0.001776879,0.0001542947,0.000891729,0.0006146008,0.0008146367,0.001632257],"category_scores_gemma":[0.0003863467,0.0002780996,0.0003713345,0.001410582,0.0003251657,0.001084552,0.0005329783,0.001595845,0.001216922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004513599,"about_ca_system_score_gemma":0.0007003166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003428655,"about_ca_topic_score_gemma":0.0004656447,"domain_scores_codex":[0.9998209,0.0000327366,0.00001947349,0.000026958,0.00007689666,0.00002311401],"domain_scores_gemma":[0.9998821,0.00004974524,0.00002334719,0.000004810935,0.00002786041,0.00001210579],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007402754,0.0001326139,0.0001610001,0.01527878,0.00005432327,0.0001991876,0.00006427951,0.0009131104,0.01263584,0.00646232,0.01108749,0.952937],"study_design_scores_gemma":[0.00002464104,0.0002393462,0.0006523261,0.002771285,0.00008894779,0.001631518,0.00005402751,0.0002733826,0.004482198,0.002744549,0.9870152,0.00002257836],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004453878,0.9977633,0.0005312856,0.0001895888,0.0001280235,0.0000144799,0.00001941535,0.0000100244,0.0008984695],"genre_scores_gemma":[0.001350583,0.9974381,0.0004613386,0.0001169937,0.00009985152,0.00001760781,0.00003176458,0.000001940211,0.000481863],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001776879,"threshold_uncertainty_score":0.005460382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0465843993243756,"score_gpt":0.3142125855572218,"score_spread":0.2676281862328462,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}