{"id":"W4210289329","doi":"10.3390/metabo12020125","title":"Secreted Protein Acidic and Rich in Cysteine (Sparc) KO Leads to an Accelerated Ageing Phenotype Which Is Improved by Exercise Whereas SPARC Overexpression Mimics Exercise Effects in Mice","year":2022,"lang":"en","type":"article","venue":"Metabolites","topic":"Bone and Dental Protein Studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Servier; Ministère de l'Éducation et de l'Enseignement supérieur; Centre Hospitalier Universitaire de Québec; Canadian Institutes of Health Research; Fonds de recherche du Québec – Nature et technologies; Université Laval","keywords":"Ageing; Osteonectin; Sarcopenia; Context (archaeology); Adipose tissue; Phenotype; Matricellular protein; Endocrinology; Muscle tissue; Internal medicine; Glycogen; Biology; Chemistry; Cell biology; Biochemistry; Medicine; Gene; Extracellular matrix; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006030475,0.0004548884,0.001068138,0.0004211747,0.0002298251,0.00007521491,0.0002129288,0.0001476223,0.0001322156],"category_scores_gemma":[0.0002124008,0.0004186366,0.00005935829,0.001630825,0.00006826887,0.0003224379,0.0005403568,0.0006353065,0.0000130939],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001238596,"about_ca_system_score_gemma":0.00007847262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002799572,"about_ca_topic_score_gemma":0.0002857441,"domain_scores_codex":[0.9971131,0.0002807012,0.000592188,0.0008441127,0.0005053395,0.0006645751],"domain_scores_gemma":[0.9988787,0.00007524386,0.0001550228,0.000460734,0.0001418192,0.0002885167],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002259941,0.000473678,0.01449589,0.0006022662,0.0000306165,0.00009075615,0.002517184,0.00001145761,0.969632,0.00001161153,0.0005544932,0.009320144],"study_design_scores_gemma":[0.01036396,0.001315963,0.06249746,0.002377632,0.0002837223,0.00002185743,0.002209744,0.003349697,0.9147763,0.0003141986,0.001477266,0.001012199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9707263,0.02484086,0.00002126647,0.0003777925,0.00008659294,0.003577167,0.000054668,0.0001021589,0.0002131923],"genre_scores_gemma":[0.995215,0.0003965106,0.001453868,0.0004821131,0.00005603161,0.001248224,0.0001217771,0.00007901929,0.0009474357],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05485566,"threshold_uncertainty_score":0.9998266,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370081340857487,"score_gpt":0.2628503338613233,"score_spread":0.2491495204527485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}