{"id":"W4210289329","doi":"10.3390/metabo12020125","title":"Secreted Protein Acidic and Rich in Cysteine (Sparc) KO Leads to an Accelerated Ageing Phenotype Which Is Improved by Exercise Whereas SPARC Overexpression Mimics Exercise Effects in Mice","year":2022,"lang":"en","type":"article","venue":"Metabolites","topic":"Bone and Dental Protein Studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Fonds de Recherche du Québec - Santé; Servier; Ministère de l'Éducation et de l'Enseignement supérieur; Centre Hospitalier Universitaire de Québec; Canadian Institutes of Health Research; Fonds de recherche du Québec – Nature et technologies; Université Laval","keywords":"Ageing; Osteonectin; Sarcopenia; Context (archaeology); Adipose tissue; Phenotype; Matricellular protein; Endocrinology; Muscle tissue; Internal medicine; Glycogen; Biology; Chemistry; Cell biology; Biochemistry; Medicine; Gene; Extracellular matrix; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002836853,0.0006948482,0.0006204043,0.0008618027,0.0003237459,0.0003489191,0.0003642581,0.0007965861,0.004011379],"category_scores_gemma":[0.0001512267,0.0003660289,0.0007800626,0.0004227635,0.0006373604,0.0004182668,0.0004193538,0.001529952,0.0008498038],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002755903,"about_ca_system_score_gemma":0.0002781357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007954084,"about_ca_topic_score_gemma":0.0009307386,"domain_scores_codex":[0.9995356,0.00004015185,0.00009067588,0.0001658863,0.00008781017,0.00007998944],"domain_scores_gemma":[0.9994343,0.00004469336,0.0001825989,0.00005664175,0.00004164132,0.0002399572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007431398,0.000113451,0.0004522548,0.0001040276,0.00002354625,0.000162198,0.00003274011,0.0001178086,0.9967064,0.0001764331,0.0001309479,0.001237036],"study_design_scores_gemma":[0.0001777529,0.001694757,0.02306987,0.00005103573,0.0001680419,0.001360023,0.000139407,0.001975831,0.965794,0.0002666914,0.005268448,0.0000340209],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907095,0.001010703,0.004081702,0.000282935,0.0001433889,0.00004166913,0.002348049,0.000296339,0.001085726],"genre_scores_gemma":[0.9774716,0.001431238,0.005520413,0.0002684029,0.00006087378,0.0002155847,0.003060569,0.0002158867,0.01175543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004011379,"threshold_uncertainty_score":0.01341945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01370081340857487,"score_gpt":0.2628503338613233,"score_spread":0.2491495204527485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}