{"id":"W4210291751","doi":"10.1002/smll.202107550","title":"Targeted Nanoparticle for Co‐delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2<b>+</b> Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis","year":2022,"lang":"en","type":"article","venue":"Small","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Biomedical Imaging and Bioengineering; National Cancer Institute; National Institutes of Health; Oregon Health and Science University","keywords":"Trastuzumab; Pertuzumab; Docetaxel; Taxane; Medicine; Breast cancer; Metastatic breast cancer; Paclitaxel; Cancer; Cancer research; Oncology; Regimen; Metastasis; Internal medicine; Drug delivery; Pharmacology; Materials science; Nanotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008435058,0.0002198163,0.0001982526,0.0001322116,0.0001297471,0.0002008526,0.0002044005,0.0003663969,0.0007197847],"category_scores_gemma":[0.00005496051,0.0001180302,0.0002077571,0.00008594237,0.00009248143,0.0001836837,0.0001579607,0.000246645,0.0002609777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003658231,"about_ca_system_score_gemma":0.0002138939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009412088,"about_ca_topic_score_gemma":0.001353736,"domain_scores_codex":[0.9999348,0.000006188786,0.000003512637,0.00002199067,0.00002248076,0.00001104719],"domain_scores_gemma":[0.9999804,0.000002202765,0.000004560618,0.000002200392,0.000004516875,0.000006076375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003817467,0.00003603085,0.00003201132,0.00002838002,0.000004471751,0.00003059748,0.000007308596,0.0001796596,0.9963613,0.0001432258,0.0001531863,0.002985595],"study_design_scores_gemma":[0.00003157449,0.0004037828,0.0006202338,0.000004334606,0.00001555442,0.0002125057,0.000005984507,0.004414659,0.9898789,0.00004129822,0.004364083,0.000006934904],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9636023,0.003430506,0.02698926,0.0003282524,0.0001097406,0.0001305188,0.0002004783,0.0004109548,0.004798069],"genre_scores_gemma":[0.9750947,0.001263813,0.01627282,0.0001393036,0.00001656634,0.00009289096,0.0002141938,0.00003745571,0.006868136],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009412088,"threshold_uncertainty_score":0.002654254,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01859024705911754,"score_gpt":0.2617607798321343,"score_spread":0.2431705327730168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}