{"id":"W4210291751","doi":"10.1002/smll.202107550","title":"Targeted Nanoparticle for Co‐delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2<b>+</b> Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis","year":2022,"lang":"en","type":"article","venue":"Small","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"National Institute of Biomedical Imaging and Bioengineering; National Cancer Institute; National Institutes of Health; Oregon Health and Science University","keywords":"Trastuzumab; Pertuzumab; Docetaxel; Taxane; Medicine; Breast cancer; Metastatic breast cancer; Paclitaxel; Cancer; Cancer research; Oncology; Regimen; Metastasis; Internal medicine; Drug delivery; Pharmacology; Materials science; Nanotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007083795,0.0002019016,0.0004633002,0.0001099587,0.0001605114,0.00003402141,0.0002066138,0.00002156123,0.0002342297],"category_scores_gemma":[0.00004066998,0.0001570672,0.00007278416,0.0003477565,0.0001840863,0.00008863095,0.0001423864,0.00005058866,0.000002444006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001976506,"about_ca_system_score_gemma":0.0001939186,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004390003,"about_ca_topic_score_gemma":0.001233681,"domain_scores_codex":[0.998154,0.0002733125,0.0004583457,0.0004155721,0.0002963898,0.0004024103],"domain_scores_gemma":[0.9988255,0.0003913528,0.00020496,0.0003260247,0.0001077511,0.000144424],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002911813,0.0006007187,0.005464753,0.00006965207,0.00003978137,0.00001816196,0.001582561,0.0004897433,0.9825334,0.0000599621,0.00022162,0.006007828],"study_design_scores_gemma":[0.005201449,0.001648144,0.03179869,0.00004886229,0.0001235909,0.00008109825,0.001663401,0.0004766181,0.9574808,0.00004340995,0.001171495,0.0002623923],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892972,0.0006891101,0.000007264054,0.003776542,0.00008935315,0.001104001,0.005006466,0.00002585754,0.00000428446],"genre_scores_gemma":[0.9985035,0.00002345673,0.0007835568,0.0002561522,0.00001623914,0.0003437565,0.000008101823,0.00002674571,0.00003848498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02633393,"threshold_uncertainty_score":0.66364,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01859024705911754,"score_gpt":0.2617607798321343,"score_spread":0.2431705327730168,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}