{"id":"W4210295999","doi":"10.1002/mds.28932","title":"<scp><i>GBA</i></scp> and <scp><i>APOE</i></scp> Impact Cognitive Decline in Parkinson's Disease: A 10‐Year Population‐Based Study","year":2022,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; European Research Council; Parkinsonfonden; National Institutes of Health; Nasjonalforeningen for Folkehelsen; Medical Research Council; Medical Research Council Canada; Kempestiftelserna; Medicinska Forskningsrådet; Umeå Universitet; Hjärnfonden; Knut och Alice Wallenbergs Stiftelse; Sanofi; Västerbotten Läns Landsting; UK Research and Innovation; University of Aberdeen; Newcastle University; Norges Forskningsråd; NIHR Cambridge Biomedical Research Centre; John and Lucille Van Geest Foundation; Academy of Medical Sciences; Bupa Foundation; Springfield Foundation; Kempe Foundation; American Parkinson Disease Association; Newcastle upon Tyne Hospitals NHS Foundation Trust; Universitetet i Stavanger; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Helse Vest; Scottish Government; Wellcome Trust; National Institute on Aging; National Institute for Health and Care Research; Parkinson's UK; Parkinson Research Foundation","keywords":"Cognitive decline; Apolipoprotein E; Dementia; Internal medicine; Population; Oncology; Psychology; Parkinson's disease; Proportional hazards model; Glucocerebrosidase; Gerontology; Medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004480694,0.000551207,0.0006142182,0.0004940532,0.0004350883,0.00007816497,0.0001856305,0.00006628659,0.0004790483],"category_scores_gemma":[0.0004188697,0.0005312443,0.0002610053,0.0007496327,0.00005189751,0.0001611246,0.0003241539,0.0003161117,0.00003599039],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000436302,"about_ca_system_score_gemma":0.0002480649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001112414,"about_ca_topic_score_gemma":0.0005380351,"domain_scores_codex":[0.9963535,0.000295411,0.0005161426,0.000964743,0.001093839,0.0007763741],"domain_scores_gemma":[0.9982054,0.0003677975,0.000239124,0.0004753408,0.00007402612,0.0006383493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003163595,0.006602883,0.9869998,0.00006547263,0.0004029235,0.0002649834,0.0005374534,0.0003450857,0.00003195875,0.00003605389,0.002635636,0.001761431],"study_design_scores_gemma":[0.01625864,0.001866842,0.9575981,0.00006434628,0.0005297658,5.98518e-7,0.006124642,0.001244651,0.00003175739,0.002780513,0.0133734,0.0001266738],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932293,0.0015894,0.00008795904,0.0004371235,0.0001397475,0.002905615,0.0005816841,0.0001334266,0.0008957594],"genre_scores_gemma":[0.9921979,0.0001189319,0.00009938193,0.003813563,0.00004883487,0.00120937,0.001159161,0.00009663425,0.001256276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02940159,"threshold_uncertainty_score":0.9997139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01284807661053729,"score_gpt":0.2783052111693001,"score_spread":0.2654571345587628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}