{"id":"W4210295999","doi":"10.1002/mds.28932","title":"<scp><i>GBA</i></scp> and <scp><i>APOE</i></scp> Impact Cognitive Decline in Parkinson's Disease: A 10‐Year Population‐Based Study","year":2022,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":120,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; European Research Council; Parkinsonfonden; National Institutes of Health; Nasjonalforeningen for Folkehelsen; Medical Research Council; Medical Research Council Canada; Kempestiftelserna; Medicinska Forskningsrådet; Umeå Universitet; Hjärnfonden; Knut och Alice Wallenbergs Stiftelse; Sanofi; Västerbotten Läns Landsting; UK Research and Innovation; University of Aberdeen; Newcastle University; Norges Forskningsråd; NIHR Cambridge Biomedical Research Centre; John and Lucille Van Geest Foundation; Academy of Medical Sciences; Bupa Foundation; Springfield Foundation; Kempe Foundation; American Parkinson Disease Association; Newcastle upon Tyne Hospitals NHS Foundation Trust; Universitetet i Stavanger; Konung Gustaf V:s och Drottning Victorias Frimurarestiftelse; Helse Vest; Scottish Government; Wellcome Trust; National Institute on Aging; National Institute for Health and Care Research; Parkinson's UK; Parkinson Research Foundation","keywords":"Cognitive decline; Apolipoprotein E; Dementia; Internal medicine; Population; Oncology; Psychology; Parkinson's disease; Proportional hazards model; Glucocerebrosidase; Gerontology; Medicine; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001568535,0.0008946446,0.0008011807,0.0005346119,0.0006526047,0.0008868339,0.0006306259,0.0009081768,0.0009777481],"category_scores_gemma":[0.002251362,0.0007669609,0.001683604,0.0007864494,0.0004326944,0.0004730992,0.0006023521,0.0007274304,0.0002590933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004107244,"about_ca_system_score_gemma":0.0003577319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008146449,"about_ca_topic_score_gemma":0.008147077,"domain_scores_codex":[0.9993041,0.0001993967,0.00007313211,0.0002660656,0.00009596272,0.00006129805],"domain_scores_gemma":[0.9983311,0.0003016795,0.000623956,0.0002673262,0.0002178936,0.0002579791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002461748,0.0001599539,0.9938757,0.00002229753,0.001671655,0.0001382811,0.0001027984,0.00008703196,0.0005409741,0.00001008318,0.00008898904,0.0008404876],"study_design_scores_gemma":[0.0001115034,0.0006528117,0.9975513,0.000007083366,0.0009367042,0.0002352205,0.00006345072,0.0002308961,0.00008807682,0.0000175684,0.00009891434,0.000006462586],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994554,0.0001770437,0.0000801397,0.00000971028,0.000003970858,0.0000105992,0.0001570366,0.000003819388,0.0001023607],"genre_scores_gemma":[0.9992338,0.00009520879,0.0001057683,0.00001964583,0.00001042229,0.00001513869,0.000381058,0.000002800296,0.0001361128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008146449,"threshold_uncertainty_score":0.01619804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01284807661053729,"score_gpt":0.2783052111693001,"score_spread":0.2654571345587628,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}