{"id":"W4210297783","doi":"10.1093/mtomcs/mfac001","title":"Zinc sequestration by human calprotectin facilitates manganese binding to the bacterial solute-binding proteins PsaA and MntC","year":2022,"lang":"en","type":"article","venue":"Metallomics","topic":"Trace Elements in Health","field":"Nursing","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Environmental Health Sciences; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Zinc; Calprotectin; Chemistry; Pathogen; Biochemistry; Zinc toxicity; Microbiology; Binding site; Biology; Biophysics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001289049,0.0001735079,0.0001709339,0.00008463443,0.0001119874,0.0001994891,0.0002313679,0.0001859412,0.0009047165],"category_scores_gemma":[0.0002366064,0.00008805108,0.0001608208,0.00007997689,0.00014655,0.0001188956,0.0002030307,0.0003186441,0.0002337183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004301856,"about_ca_system_score_gemma":0.0001840404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001982147,"about_ca_topic_score_gemma":0.002060084,"domain_scores_codex":[0.9998815,0.00001940889,0.000007570449,0.00002409944,0.00003644693,0.00003081283],"domain_scores_gemma":[0.9998991,0.00002335251,0.00002711344,0.000008007621,0.00001558098,0.00002684726],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001195516,0.00001912076,0.0004123252,0.00001691348,0.000003455802,0.00003700076,0.00001201021,0.0000598218,0.9986798,0.00003683965,0.00004148832,0.0005615915],"study_design_scores_gemma":[0.00002338445,0.000157664,0.01111263,0.000005546725,0.000008165274,0.0002084248,0.00002906781,0.004513563,0.982296,0.0000335965,0.001606153,0.00000565035],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982303,0.0003940578,0.0008422619,0.00005770226,0.000007306979,0.000007144047,0.00006687735,0.00002438888,0.0003701407],"genre_scores_gemma":[0.9979447,0.0001142766,0.0007941377,0.00003795493,0.00000246537,0.000007660526,0.0002111198,0.000008543766,0.0008790987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001982147,"threshold_uncertainty_score":0.003941238,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03105519928847747,"score_gpt":0.2966319992846549,"score_spread":0.2655767999961774,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}