{"id":"W4210298250","doi":"10.1016/j.bmc.2022.116628","title":"Anti-Lea monoclonal antibody SPM 522 recognizes an extended Lea epitope","year":2022,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Epitope; Monoclonal antibody; Residue (chemistry); Tetrasaccharide; Epitope mapping; Stereochemistry; Binding site; Glycoside; Biochemistry; Antibody; Peptide sequence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002873555,0.0006131887,0.0003230855,0.000553233,0.0003207588,0.0003926553,0.0006349506,0.0007454942,0.01108201],"category_scores_gemma":[0.0002327574,0.0002933899,0.0005426759,0.0002579971,0.0002334128,0.0003980186,0.0004763878,0.00123203,0.005041952],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003165525,"about_ca_system_score_gemma":0.0002262373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003534381,"about_ca_topic_score_gemma":0.0006894807,"domain_scores_codex":[0.9997186,0.00003614702,0.00001555035,0.00006329967,0.00005975999,0.0001066947],"domain_scores_gemma":[0.9997998,0.00005510077,0.00002436887,0.00003184441,0.00003469506,0.00005427554],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001600737,0.00005962712,0.0002815916,0.00004654237,0.0000134823,0.0001204117,0.00001518269,0.00005093106,0.9935094,0.0003020167,0.0005033124,0.004937467],"study_design_scores_gemma":[0.0001552646,0.0006907283,0.007140804,0.00003229458,0.00006136259,0.002265379,0.0000648428,0.002453541,0.9487744,0.0003667545,0.03797166,0.00002292638],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9314452,0.004348418,0.03535871,0.0008605972,0.000298167,0.0001780844,0.001149571,0.0007041962,0.02565707],"genre_scores_gemma":[0.9431271,0.002332467,0.01929621,0.0007536554,0.0001660194,0.0002133026,0.004841463,0.00008207504,0.02918757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01108201,"threshold_uncertainty_score":0.03707308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02882075599730082,"score_gpt":0.3328163553487742,"score_spread":0.3039955993514734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}