{"id":"W4210316410","doi":"10.1172/jci.insight.151683","title":"Accumulation of meningeal lymphocytes correlates with white matter lesion activity in progressive multiple sclerosis","year":2022,"lang":"en","type":"article","venue":"JCI Insight","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Perelman School of Medicine, University of Pennsylvania; Genentech; Multiple Sclerosis Society; EMD Serono; University of Pennsylvania; National Institute of Allergy and Infectious Diseases; Biogen; Celgene; University of Toronto; King's College London; Atara Biotherapeutics; National Multiple Sclerosis Society; GlaxoSmithKline; Bristol-Myers Squibb; Sanofi","keywords":"Multiple sclerosis; White matter; Lesion; Neural correlates of consciousness; Neuroscience; Medicine; Pathology; Psychology; Immunology; Magnetic resonance imaging; Radiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002399148,0.0002311249,0.0002254843,0.001160104,0.0001934312,0.0003832896,0.0001091613,0.000241779,0.001325652],"category_scores_gemma":[0.001179659,0.0001700915,0.00008143052,0.000478166,0.0003103684,0.0002621138,0.0002727872,0.0003248989,0.0002783771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001437937,"about_ca_system_score_gemma":0.0001151989,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001072074,"about_ca_topic_score_gemma":0.001533458,"domain_scores_codex":[0.9998676,0.00003416397,0.00001607112,0.0000305315,0.00003375619,0.00001795298],"domain_scores_gemma":[0.9991108,0.0001737699,0.0004397313,0.00006644717,0.00007632954,0.000132971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001553681,0.00009866768,0.908712,0.00006735376,0.00009627061,0.001243558,0.0005484897,0.0001558468,0.0737021,0.00006578297,0.0001416189,0.01361457],"study_design_scores_gemma":[0.00001210462,0.0001715919,0.9953985,0.000005783252,0.00002242479,0.001847643,0.0001168674,0.000111883,0.002075952,0.00005042971,0.0001831635,0.000003595252],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991058,0.0003828855,0.000104515,0.00001444765,0.000001142788,0.00000369499,0.00004215763,0.000007038021,0.0003383822],"genre_scores_gemma":[0.9994971,0.0001368315,0.0001369006,0.00001000069,0.000005572885,0.000003219969,0.00005541983,0.000001922748,0.0001530849],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001325652,"threshold_uncertainty_score":0.004434824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1342872729589648,"score_gpt":0.3373721008325079,"score_spread":0.2030848278735431,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}