{"id":"W4210321193","doi":"10.1093/cid/ciac115","title":"Genital Immune Cell Activation and Tenofovir Gel Efficacy: A Case-Control Study","year":2022,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS Research and Interventions","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"European and Developing Countries Clinical Trials Partnership; Canadian Institutes of Health Research; National Institutes of Health; National Institute of Allergy and Infectious Diseases; African Academy of Sciences; Royal Society; Department of Science and Technology, Republic of South Africa; Tides Foundation; U.S. President’s Emergency Plan for AIDS Relief; United States Agency for International Development","keywords":"Medicine; Immune system; Tenofovir; Immunology; Intracellular; Human immunodeficiency virus (HIV); Pre-exposure prophylaxis; Deoxyadenosine; Immunity; Virology; Internal medicine; Biology; Men who have sex with men; Adenosine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"observational","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001300381,0.0007026551,0.00070445,0.001263157,0.001130242,0.001164584,0.0006662745,0.001403136,0.00305981],"category_scores_gemma":[0.003210798,0.0008626966,0.0007675143,0.001235731,0.0008836784,0.0006764717,0.0005796335,0.0008646025,0.0003110746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000562615,"about_ca_system_score_gemma":0.000382164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006062298,"about_ca_topic_score_gemma":0.004193513,"domain_scores_codex":[0.9986022,0.000434599,0.0001376061,0.0004145142,0.0002081113,0.0002030232],"domain_scores_gemma":[0.9984189,0.0005346977,0.0004014182,0.0002868034,0.0001471933,0.0002108474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001093824,0.0007165067,0.9933265,0.00006495113,0.0003463188,0.001551636,0.0004161063,0.00002758473,0.0006224231,0.00008781805,0.000139108,0.001607182],"study_design_scores_gemma":[0.0002469889,0.00210324,0.989114,0.00004245493,0.000481764,0.00576662,0.0009343025,0.0004245997,0.0002356818,0.00009862889,0.0005221371,0.00002954753],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988099,0.0004927025,0.0001014941,0.00002438343,0.000007848211,0.00004162054,0.0000815613,0.000002895087,0.0004375198],"genre_scores_gemma":[0.9995356,0.000158289,0.0000831654,0.00002465262,0.00001364668,0.00001917406,0.00006166886,0.000001941523,0.0001017037],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006062298,"threshold_uncertainty_score":0.01205403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03149389327511393,"score_gpt":0.3794690343998419,"score_spread":0.347975141124728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}