{"id":"W4210323406","doi":"10.3389/fpsyt.2021.770592","title":"Early Clinical Effects of Novel Partial D3/D2 Agonist Cariprazine in Schizophrenia Patients With Predominantly Negative Symptoms (Open-Label, Non-controlled Study)","year":2022,"lang":"en","type":"article","venue":"Frontiers in Psychiatry","topic":"Schizophrenia research and treatment","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Akathisia; Partial agonist; Positive and Negative Syndrome Scale; Tolerability; Extrapyramidal symptoms; Risperidone; Schizophrenia (object-oriented programming); Internal medicine; Antipsychotic; Lurasidone; Dopamine receptor D3; Psychology; Psychiatry; Medicine; Agonist; Dopamine receptor D2; Psychosis; Adverse effect; Dopamine; Receptor","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007621029,0.0007191676,0.001454542,0.0002304626,0.0003143633,0.0003744401,0.0003803261,0.0006926899,0.002047736],"category_scores_gemma":[0.0006280027,0.0003108279,0.0007501835,0.0001848455,0.0005339233,0.0004043388,0.0001938247,0.001106533,0.0003441592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003020888,"about_ca_system_score_gemma":0.0004356852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007482262,"about_ca_topic_score_gemma":0.001955868,"domain_scores_codex":[0.9997334,0.0001022887,0.00002772346,0.00005637928,0.00002962333,0.00005045129],"domain_scores_gemma":[0.9994426,0.0001245567,0.0001346601,0.00004954247,0.00005620851,0.0001924188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8306023,0.04059544,0.01610928,0.0009922223,0.001006419,0.0004712831,0.0002726475,0.0003429225,0.05912722,0.00004900193,0.0007093461,0.04972197],"study_design_scores_gemma":[0.2083156,0.6877936,0.09440695,0.00005883283,0.0006893938,0.0005068447,0.0001195293,0.0007461774,0.006068708,0.00005671263,0.001195443,0.00004219226],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981861,0.001019408,0.00007587695,0.00003598019,0.00002545341,0.0002468042,0.0001744878,0.00001435106,0.0002215288],"genre_scores_gemma":[0.99735,0.0006940763,0.0003001894,0.0001327226,0.00008453918,0.0003042263,0.0005198803,0.000003334037,0.0006109866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002047736,"threshold_uncertainty_score":0.006850421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01242157417722702,"score_gpt":0.3059931288176572,"score_spread":0.2935715546404302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}