{"id":"W4210327457","doi":"10.1002/1873-3468.14303","title":"Improved synthesis of an ergothioneine PET radioligand for imaging oxidative stress in Alzheimer’s disease","year":2022,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute on Aging; National Institutes of Health","keywords":"Radioligand; Ergothioneine; Oxidative stress; Chemistry; In vivo; Biodistribution; Pharmacology; Radiosynthesis; Biochemistry; Antioxidant; Medicine; In vitro; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003905346,0.0006492222,0.0004925872,0.0002832156,0.0002062092,0.0003007161,0.0007122722,0.0008787471,0.001602028],"category_scores_gemma":[0.000239293,0.0003565627,0.0003463915,0.0002697576,0.0002004644,0.0003235364,0.0003138746,0.0006365806,0.00118341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003915792,"about_ca_system_score_gemma":0.0004183456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006962509,"about_ca_topic_score_gemma":0.00140602,"domain_scores_codex":[0.9998417,0.00004050874,0.00001618386,0.00003753441,0.00002799148,0.00003602187],"domain_scores_gemma":[0.9998839,0.00001878203,0.00002044352,0.00001699147,0.00003319902,0.00002660741],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006895131,0.00002381033,0.00003992358,0.00007468266,0.00001019781,0.0001647813,0.00002657722,0.0001930278,0.9969801,0.0001295158,0.00009873006,0.002189663],"study_design_scores_gemma":[0.00004538831,0.0005032669,0.0006518879,0.0000128827,0.00004030496,0.0007065714,0.00002163405,0.0009173987,0.9881005,0.00006337879,0.008916512,0.00002024924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.7858701,0.008545545,0.1937588,0.0008233047,0.0002289398,0.0009139829,0.002487159,0.0006794875,0.006692613],"genre_scores_gemma":[0.8469572,0.004728364,0.1320775,0.0004195723,0.00007536513,0.0004841486,0.003310962,0.0002012957,0.01174555],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001602028,"threshold_uncertainty_score":0.005359292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01948285227584843,"score_gpt":0.2824265179993749,"score_spread":0.2629436657235265,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}