{"id":"W4210338897","doi":"10.7554/elife.75508","title":"Zinc finger protein Zfp335 controls early T-cell development and survival through β-selection-dependent and -independent mechanisms","year":2022,"lang":"en","type":"article","venue":"eLife","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Major International Joint Research Programme; National Natural Science Foundation of China","keywords":"Transcription factor; Thymocyte; Zinc finger; Transcription (linguistics); Intracellular; Transcriptome; Double negative; Apoptosis; Cellular differentiation; Regulation of gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001791111,0.0004283544,0.0002907973,0.000243821,0.0002805799,0.0004222299,0.0004196043,0.0003844674,0.001799174],"category_scores_gemma":[0.0001808463,0.0002449235,0.0002821615,0.0002006537,0.0003132232,0.0003018323,0.0004713619,0.0006506587,0.0009373007],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004134341,"about_ca_system_score_gemma":0.0002899722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00139636,"about_ca_topic_score_gemma":0.002028917,"domain_scores_codex":[0.99975,0.00001507144,0.00001539578,0.00007742822,0.0000729409,0.00006922991],"domain_scores_gemma":[0.9998823,0.000008888417,0.00005478348,0.000009251397,0.00001031883,0.00003436138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001889059,0.000009680219,0.0008011167,0.00009983002,0.000008140203,0.0001453502,0.00003175674,0.0001576483,0.993813,0.0002933896,0.0002414637,0.004209602],"study_design_scores_gemma":[0.00008213346,0.0001351348,0.02392556,0.00003841523,0.00004837452,0.000675787,0.00007740333,0.003512336,0.9541526,0.0002474663,0.0170855,0.00001930497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9637287,0.003915364,0.02257209,0.0002804956,0.00008378865,0.00005173804,0.003068054,0.001434171,0.004865619],"genre_scores_gemma":[0.9881597,0.0009684814,0.004912005,0.00008081475,0.00001201516,0.00002985977,0.001328828,0.00008273217,0.004425719],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001799174,"threshold_uncertainty_score":0.006018817,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116609699553764,"score_gpt":0.2089308999438552,"score_spread":0.1972699299884788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}