{"id":"W4210342713","doi":"10.1158/1078-0432.ccr-21-3940","title":"Tumor Genomic Testing for >4,000 Men with Metastatic Castration-resistant Prostate Cancer in the Phase III Trial PROfound (Olaparib)","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; Centre Hospitalier de l’Université de Montréal","funders":"Merck Sharp and Dohme; National Institute for Health and Care Research; Merck; AstraZeneca","keywords":"Olaparib; Prostate cancer; Homologous recombination; Cancer; Clinical trial; Homologous chromosome; Prostate","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001526901,0.0002932993,0.0003267954,0.0003926376,0.0002124597,0.0004186085,0.0002797257,0.0002732737,0.00104177],"category_scores_gemma":[0.001528998,0.0002037564,0.0001539879,0.0002956974,0.0003018634,0.0002961572,0.0003342327,0.0003004513,0.0002911651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003022141,"about_ca_system_score_gemma":0.0002626489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005640669,"about_ca_topic_score_gemma":0.0008734405,"domain_scores_codex":[0.999359,0.0002117778,0.00005330182,0.0001646327,0.0001597997,0.00005166905],"domain_scores_gemma":[0.9993027,0.000211282,0.0002371019,0.00005843523,0.00009014216,0.0001003018],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002441616,0.0002375821,0.9646598,0.00005820924,0.00005798485,0.0002221578,0.00009626763,0.0005229114,0.008614081,0.0000363281,0.0004386224,0.02261452],"study_design_scores_gemma":[0.0003508884,0.005648463,0.980055,0.00001482365,0.00008506625,0.001702967,0.00008596636,0.001616636,0.008447457,0.00006641611,0.001916856,0.000009452167],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979778,0.0004557561,0.0003775147,0.0000396632,0.000004770852,0.00006359061,0.0005187092,0.00002287368,0.0005394249],"genre_scores_gemma":[0.9979094,0.0001077522,0.0007988014,0.00006077943,0.00001301858,0.00003848068,0.0008240995,0.000004205359,0.0002435633],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001526901,"threshold_uncertainty_score":0.008075178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4004069388603253,"score_gpt":0.5604908869630105,"score_spread":0.1600839481026852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}