{"id":"W4210342713","doi":"10.1158/1078-0432.ccr-21-3940","title":"Tumor Genomic Testing for >4,000 Men with Metastatic Castration-resistant Prostate Cancer in the Phase III Trial PROfound (Olaparib)","year":2022,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Cancer Foundation; Centre Hospitalier de l’Université de Montréal","funders":"Merck Sharp and Dohme; National Institute for Health and Care Research; Merck; AstraZeneca","keywords":"Olaparib; Prostate cancer; Homologous recombination; Cancer; Clinical trial; Homologous chromosome; Prostate","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.009197658,0.0002630176,0.0007029075,0.0002885746,0.0009853375,0.0001545717,0.0005077369,0.00005009642,0.0009242903],"category_scores_gemma":[0.0009137746,0.0001608255,0.0001575349,0.001457181,0.0006412605,0.000121427,0.0002043391,0.001724866,0.000008978225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001202796,"about_ca_system_score_gemma":0.005333815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002984677,"about_ca_topic_score_gemma":0.002208838,"domain_scores_codex":[0.9938635,0.001295856,0.00102188,0.0008626879,0.001779563,0.001176545],"domain_scores_gemma":[0.9950444,0.003163727,0.00022168,0.000613192,0.0006547572,0.000302262],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8787813,0.005964133,0.02024931,0.0008062629,0.000869167,0.0009598373,0.004179261,0.0004824475,0.01085251,0.0002146484,0.02015926,0.05648193],"study_design_scores_gemma":[0.7822445,0.05378617,0.02327231,0.0007401796,0.0008541077,0.000107494,0.009364329,0.003923767,0.0007938244,0.001284325,0.1226309,0.0009981347],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750471,0.002784809,0.000009015417,0.007404959,0.0002011243,0.01273128,0.0007348672,0.00003491509,0.001051971],"genre_scores_gemma":[0.9639415,0.0003167044,0.0004014036,0.0003443285,0.0007422807,0.02807586,0.000176211,0.00007738431,0.005924376],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1024716,"threshold_uncertainty_score":0.999989,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4004069388603253,"score_gpt":0.5604908869630105,"score_spread":0.1600839481026852,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}