{"id":"W4210346055","doi":"10.3390/biomedicines10020362","title":"AAV-Vectored Expression of the Vascular Normalizing Agents 3TSR and Fc3TSR, and the Anti-Angiogenic Bevacizumab Extends Survival in a Murine Model of End-Stage Epithelial Ovarian Carcinoma","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; University of Guelph","funders":"University of Guelph","keywords":"Oncolytic virus; Bevacizumab; Medicine; Immunohistochemistry; Ovarian cancer; CD8; Immunotherapy; Cancer research; Flow cytometry; Pathology; Cancer; Immunology; Internal medicine; Immune system; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002410434,0.0003605032,0.0003578881,0.0003723123,0.0001315552,0.0003475711,0.0002604162,0.0004292639,0.0006893244],"category_scores_gemma":[0.000117967,0.0001801297,0.0003028818,0.0001511323,0.000320008,0.0002763589,0.0001518293,0.0009286657,0.0001759401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004173064,"about_ca_system_score_gemma":0.0003767959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001321299,"about_ca_topic_score_gemma":0.001745356,"domain_scores_codex":[0.9997523,0.00003105949,0.00002677915,0.00005826666,0.00006620895,0.00006523118],"domain_scores_gemma":[0.9998292,0.00001980614,0.00006469334,0.00001910665,0.00001609083,0.0000511343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003015419,0.0001707235,0.0001359023,0.00002602027,0.000005260128,0.00002957072,0.00002535331,0.0001843721,0.9977028,0.0001163411,0.0000395965,0.001262574],"study_design_scores_gemma":[0.0001058488,0.005305578,0.00338418,0.00001427274,0.00003640648,0.000265362,0.00004269223,0.002988308,0.9853977,0.0000757654,0.002374786,0.00000904301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996283,0.0006488227,0.001941393,0.00007815447,0.00003634177,0.00005201937,0.0002431121,0.00007806732,0.0006392536],"genre_scores_gemma":[0.9927894,0.0006840199,0.002696796,0.0000370986,0.00001406574,0.00008312891,0.0003982857,0.00001983803,0.003277299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001321299,"threshold_uncertainty_score":0.003027797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02033716449189283,"score_gpt":0.2699764508138688,"score_spread":0.249639286321976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}