{"id":"W4210346055","doi":"10.3390/biomedicines10020362","title":"AAV-Vectored Expression of the Vascular Normalizing Agents 3TSR and Fc3TSR, and the Anti-Angiogenic Bevacizumab Extends Survival in a Murine Model of End-Stage Epithelial Ovarian Carcinoma","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Juravinski Cancer Centre; University of Guelph","funders":"University of Guelph","keywords":"Oncolytic virus; Bevacizumab; Medicine; Immunohistochemistry; Ovarian cancer; CD8; Immunotherapy; Cancer research; Flow cytometry; Pathology; Cancer; Immunology; Internal medicine; Immune system; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009105949,0.0001497201,0.00027305,0.0001214865,0.0001382064,0.000006069288,0.0003298115,0.00006009761,0.00003036662],"category_scores_gemma":[0.00005247048,0.00009177496,0.0001090441,0.0002521403,0.0004454771,0.000004504589,0.0005789251,0.0001095757,6.96415e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001430701,"about_ca_system_score_gemma":0.00009891133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00038371,"about_ca_topic_score_gemma":0.0001003232,"domain_scores_codex":[0.99842,0.0003657185,0.0002974932,0.0002875804,0.0004035896,0.0002256385],"domain_scores_gemma":[0.9992594,0.00003365899,0.0001296337,0.0004743419,0.00005175379,0.00005117301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001457239,0.00006305621,0.01203985,0.00005558581,0.00005922603,0.000003380895,0.0005974945,0.0002935774,0.9847234,0.00002600296,0.0000289277,0.0006522915],"study_design_scores_gemma":[0.01165023,0.00121052,0.08370821,0.00005092809,0.0000795934,0.00002051179,0.0008237013,0.008494993,0.8929024,0.00009723862,0.000710511,0.0002511888],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949923,0.004097487,0.00005826023,0.0002310148,0.000101323,0.0003454576,0.0001438243,0.000003324371,0.00002699074],"genre_scores_gemma":[0.999184,0.0004511551,0.00004275744,0.00005896132,0.00007222097,0.0000401576,0.00004221885,0.00002047896,0.00008802586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09182099,"threshold_uncertainty_score":0.3742474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02033716449189283,"score_gpt":0.2699764508138688,"score_spread":0.249639286321976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}