{"id":"W4210347913","doi":"10.1002/mnfr.202100853","title":"Cranberry Proanthocyanidin and Its Microbial Metabolite 3,4‐Dihydroxyphenylacetic Acid, but Not 3‐(4‐Hydroxyphenyl)‐Propionic Acid, Partially Reverse Pro‐Inflammatory microRNA Responses in Human Intestinal Epithelial Cells","year":2022,"lang":"en","type":"article","venue":"Molecular Nutrition & Food Research","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; The Wilson Centre; Hospital for Sick Children; University of Toronto","funders":"Ocean Spray; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; International Business Machines Corporation","keywords":"Wnt signaling pathway; microRNA; Gut flora; Chemistry; Inflammation; Cell biology; Cell growth; Homeostasis; Signal transduction; Metabolite; Biology; Apoptosis; Biochemistry; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002341086,0.0004091074,0.0003879427,0.0005334964,0.0007622897,0.000138417,0.0005946014,0.0002645895,0.0001468734],"category_scores_gemma":[0.0003491044,0.0004916907,0.0002203921,0.0006384636,0.0003533893,0.00003244222,0.001006859,0.0008891994,0.00002228635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002314902,"about_ca_system_score_gemma":0.0005434693,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002835915,"about_ca_topic_score_gemma":0.00005214689,"domain_scores_codex":[0.9935982,0.002488044,0.0007324634,0.001191169,0.0009379048,0.001052246],"domain_scores_gemma":[0.9983704,0.00004512011,0.0002043775,0.0006941491,0.0003982908,0.0002876297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00220779,0.0005773097,0.00008948305,0.0003478341,0.00008619294,0.0002068988,0.000107719,0.0001528883,0.9951639,0.0003417305,0.0005750154,0.0001432305],"study_design_scores_gemma":[0.003480187,0.001259938,0.0005757638,0.0001017299,0.00004675913,0.0001795505,0.0001207906,0.0001594309,0.9827725,0.0004139329,0.01038404,0.0005054231],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901343,0.006219097,0.000195344,0.0006022846,0.000136854,0.002258545,0.0003451502,0.00004340989,0.00006500196],"genre_scores_gemma":[0.99672,0.0001990386,0.0007758354,0.0001815115,0.0002821369,0.001045519,0.0003887869,0.0001096856,0.000297499],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01239146,"threshold_uncertainty_score":0.9997535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02961819232279779,"score_gpt":0.2957949643232431,"score_spread":0.2661767720004453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}