{"id":"W4210347913","doi":"10.1002/mnfr.202100853","title":"Cranberry Proanthocyanidin and Its Microbial Metabolite 3,4‐Dihydroxyphenylacetic Acid, but Not 3‐(4‐Hydroxyphenyl)‐Propionic Acid, Partially Reverse Pro‐Inflammatory microRNA Responses in Human Intestinal Epithelial Cells","year":2022,"lang":"en","type":"article","venue":"Molecular Nutrition & Food Research","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; The Wilson Centre; Hospital for Sick Children; University of Toronto","funders":"Ocean Spray; Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; International Business Machines Corporation","keywords":"Wnt signaling pathway; microRNA; Gut flora; Chemistry; Inflammation; Cell biology; Cell growth; Homeostasis; Signal transduction; Metabolite; Biology; Apoptosis; Biochemistry; Gene; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001017928,0.0002816519,0.0002150431,0.0001336549,0.00008875567,0.0001494558,0.000100048,0.000217633,0.001328337],"category_scores_gemma":[0.0001195465,0.0001030666,0.0002402167,0.0001080778,0.0001733708,0.0001546654,0.0001152824,0.0004141961,0.0002417663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001301112,"about_ca_system_score_gemma":0.0002372287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005139575,"about_ca_topic_score_gemma":0.0006530604,"domain_scores_codex":[0.9999294,0.00001541179,0.000006245315,0.00001622673,0.00001423117,0.00001850733],"domain_scores_gemma":[0.999905,0.00001999539,0.00002822923,0.00001338431,0.00001008926,0.00002319873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003620007,0.00003733743,0.00008799104,0.00004977329,0.000005440857,0.00002251208,0.00000633721,0.0000178954,0.998173,0.00001302241,0.00001626713,0.001208449],"study_design_scores_gemma":[0.00003246505,0.0009570892,0.003480403,0.000004891259,0.00002002116,0.0001658003,0.00001275228,0.0001423876,0.9938232,0.000008592961,0.001350241,0.000002141061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947549,0.0031675,0.0008843403,0.00006497446,0.00002108608,0.00003429217,0.0002351733,0.00004389371,0.000793836],"genre_scores_gemma":[0.9948155,0.001270737,0.001904907,0.00006234373,0.00001375847,0.00003421491,0.0004596533,0.00001295638,0.00142586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001328337,"threshold_uncertainty_score":0.004443765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02961819232279779,"score_gpt":0.2957949643232431,"score_spread":0.2661767720004453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}