{"id":"W4210357221","doi":"10.1161/circgen.121.003391","title":"Rare Variation in Drug Metabolism and Long QT Genes and the Genetic Susceptibility to Acquired Long QT Syndrome","year":2022,"lang":"en","type":"article","venue":"Circulation Genomic and Precision Medicine","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Pharmacogenomics; Genetic predisposition; Genetic variation; Gene; Pharmacogenetics; Long QT syndrome; Personalized medicine; Precision medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001212504,0.0001626626,0.000506259,0.0001952771,0.0003027261,0.00001313184,0.00005703196,0.0000624305,0.0002028316],"category_scores_gemma":[0.0001740867,0.0001173312,0.00004445585,0.0002659884,0.0002026477,0.00005621454,0.0001469744,0.0001804798,0.000002800695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007099889,"about_ca_system_score_gemma":0.00004819993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001204338,"about_ca_topic_score_gemma":0.00002777162,"domain_scores_codex":[0.9982762,0.0004197065,0.0004108699,0.0004608077,0.0002412196,0.0001912195],"domain_scores_gemma":[0.9990438,0.0003763234,0.0001056918,0.0002929445,0.00005139994,0.0001298397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.009855431,0.0002141339,0.4149377,0.0005171945,0.0005289071,0.002081364,0.04295292,0.01486481,0.1763785,0.001850062,0.0008138932,0.3350051],"study_design_scores_gemma":[0.003878765,0.0001180862,0.9894701,0.00004019906,0.0001628888,0.001964348,0.0002569146,0.0022176,0.00002302832,0.001505473,0.000246195,0.0001164208],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780256,0.01691047,0.001097135,0.002644759,0.0002507962,0.00100415,0.000006124531,0.00001924427,0.00004168284],"genre_scores_gemma":[0.9977484,0.0008564073,0.0001310467,0.0007958364,0.0002152633,0.0000632107,0.00003733084,0.00001552604,0.0001369985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5745324,"threshold_uncertainty_score":0.4784626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01017970019995965,"score_gpt":0.2449505941852251,"score_spread":0.2347708939852654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}