{"id":"W4210359431","doi":"10.1016/j.jtct.2022.01.025","title":"A Prospective, Multicenter Study of Closed-System Extracorporeal Photopheresis for Children with Steroid-Refractory Acute Graft-versus-Host Disease","year":2022,"lang":"en","type":"article","venue":"Transplantation and Cellular Therapy","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Incyte; Sanofi Genzyme; bluebird bio; Jazz Pharmaceuticals; Pharmacyclics; Sanofi; Sucampo Pharmaceuticals; Mallinckrodt Pharmaceuticals; Gilead Sciences","keywords":"Medicine; Extracorporeal Photopheresis; Adverse effect; Refractory (planetary science); Photopheresis; Clinical endpoint; Immunosuppression; Graft-versus-host disease; Internal medicine; Extracorporeal; Surgery; Gastroenterology; Clinical trial; Disease","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001840858,0.0009744954,0.001304986,0.0006246465,0.0009177143,0.001052716,0.0006377812,0.0009362234,0.001820468],"category_scores_gemma":[0.004549794,0.0003913605,0.0009349407,0.001262273,0.001317835,0.001181673,0.0005379928,0.001144915,0.000259587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008868023,"about_ca_system_score_gemma":0.001599039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003231626,"about_ca_topic_score_gemma":0.003021229,"domain_scores_codex":[0.9981424,0.001025137,0.0001391985,0.0003031127,0.0001509332,0.0002392367],"domain_scores_gemma":[0.9965339,0.001079469,0.001077852,0.0002828958,0.000236193,0.0007898006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.02563173,0.003952779,0.9622888,0.00008473487,0.0006324492,0.0008848193,0.0005411568,0.0001467274,0.001317145,0.0001237698,0.000235398,0.004160536],"study_design_scores_gemma":[0.0106121,0.03995334,0.9423254,0.00005346561,0.0007556651,0.002406993,0.001660624,0.0004885501,0.0005595483,0.0001103691,0.001022029,0.00005196605],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995115,0.0001857213,0.00003910915,0.00002303207,0.000006255005,0.00004407588,0.00007645634,0.000001562036,0.0001124007],"genre_scores_gemma":[0.9991552,0.0001695602,0.0001450563,0.0000654332,0.00003635184,0.000071747,0.000268207,0.000003394197,0.00008503267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003231626,"threshold_uncertainty_score":0.009735525,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01568047141291025,"score_gpt":0.2536606346793648,"score_spread":0.2379801632664545,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}