{"id":"W4210381122","doi":"10.1002/pbc.29534","title":"Success rates for US and Canadian anticancer drug development efforts in pediatric oncology","year":2022,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Genome Canada","keywords":"Medicine; Psychological intervention; Clinical trial; Randomized controlled trial; Drug development; Phases of clinical research; Pediatric oncology; Oncology; Cancer; Drug; Intensive care medicine; Family medicine; Internal medicine; Pharmacology; Nursing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","metaepi_broad"],"consensus_categories":[],"category_scores_codex":[0.04128274,0.0005117133,0.0006816958,0.006273186,0.002257205,0.002792465,0.002007722,0.001058522,0.005543712],"category_scores_gemma":[0.1338329,0.000402718,0.001238149,0.008760693,0.001793618,0.001726661,0.003000148,0.001396451,0.0005416619],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.02929476,"about_ca_system_score_gemma":0.06784536,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.7814961,"about_ca_topic_score_gemma":0.8162478,"domain_scores_codex":[0.9658287,0.009618494,0.003229079,0.003546209,0.01396957,0.003808023],"domain_scores_gemma":[0.8538647,0.04793433,0.04528948,0.006281381,0.03170225,0.01492786],"domain_codex":null,"domain_gemma":"evaluation","domain_candidate":"evaluation","domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007311084,0.0001157775,0.8383444,0.001352081,0.0004108228,0.0001239106,0.001847662,0.00126484,0.0002345683,0.00539399,0.02249738,0.1276836],"study_design_scores_gemma":[0.0001117381,0.0002367822,0.9593408,0.0006118401,0.0002633977,0.0002907528,0.001254944,0.00149969,0.0006206796,0.0005862614,0.03513007,0.00005306522],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7537743,0.04515729,0.006887499,0.03294252,0.0002935388,0.002945176,0.05644794,0.0008064917,0.1007451],"genre_scores_gemma":[0.9701245,0.009485353,0.005817417,0.002653112,0.00009379151,0.0006812642,0.007902599,0.00008033828,0.003161578],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9993183,"threshold_uncertainty_score":0.4395814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03242182185610693,"score_gpt":0.3758625520089151,"score_spread":0.3434407301528082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}