{"id":"W4210381122","doi":"10.1002/pbc.29534","title":"Success rates for US and Canadian anticancer drug development efforts in pediatric oncology","year":2022,"lang":"en","type":"article","venue":"Pediatric Blood & Cancer","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; Genome Canada","keywords":"Medicine; Psychological intervention; Clinical trial; Randomized controlled trial; Drug development; Phases of clinical research; Pediatric oncology; Oncology; Cancer; Drug; Intensive care medicine; Family medicine; Internal medicine; Pharmacology; Nursing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005607223,0.0001769585,0.0003771468,0.0002647162,0.0003955412,0.00001904287,0.0001091622,0.00005289809,0.0005940447],"category_scores_gemma":[0.00008650473,0.0001652251,0.00004419047,0.0005961994,0.00003037204,0.00008306069,0.0001283186,0.0003741514,0.000003262222],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004138767,"about_ca_system_score_gemma":0.001851433,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.04211719,"about_ca_topic_score_gemma":0.1084969,"domain_scores_codex":[0.9983609,0.00006190694,0.0003388165,0.0003859755,0.000248623,0.0006038112],"domain_scores_gemma":[0.99896,0.000377635,0.0001250701,0.00009966108,0.00007065355,0.0003669614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002112683,0.0001812124,0.9862177,0.0003388494,0.00007655881,0.00009190363,0.0005453907,0.00003011763,0.000004029616,0.00002008287,0.005072123,0.007210816],"study_design_scores_gemma":[0.003529803,0.0001937808,0.4910315,0.000005742396,0.001013142,0.00003054316,0.0001319308,0.000105704,0.00006700135,0.00003029704,0.5035961,0.000264515],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9502422,0.04118078,0.00000139664,0.005906194,0.0006425458,0.0007692034,0.00006292345,0.00002044601,0.001174309],"genre_scores_gemma":[0.9722025,0.02229701,0.0002564085,0.00275583,0.001068775,0.00108562,0.00001752998,0.00002531109,0.0002910181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.498524,"threshold_uncertainty_score":0.9642614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03242182185610693,"score_gpt":0.3758625520089151,"score_spread":0.3434407301528082,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}