{"id":"W4210382059","doi":"10.1016/j.jaci.2021.12.628","title":"Influence of Baseline Total IgE and History of Previous Omalizumab Use on the Impact of Mepolizumab in Reducing Rate of Severe Asthma Exacerbations: Results From the Real-World REALITI-A Study","year":2022,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Omalizumab; Mepolizumab; Medicine; Asthma; Baseline (sea); Immunoglobulin E; Asthma exacerbations; Internal medicine; Immunology; Antibody; Eosinophil","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001895702,0.0007714277,0.001457965,0.0002457834,0.0003135034,0.0007943518,0.0005538962,0.0009450052,0.001225497],"category_scores_gemma":[0.003105683,0.0004162047,0.002442605,0.0003669109,0.0004390979,0.0006398588,0.0004426014,0.001048881,0.0001659263],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003756212,"about_ca_system_score_gemma":0.0004240124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002173253,"about_ca_topic_score_gemma":0.002906712,"domain_scores_codex":[0.998722,0.0006951633,0.0001135111,0.0002119103,0.0001268599,0.0001304913],"domain_scores_gemma":[0.9975833,0.001197354,0.000515396,0.0002129361,0.00009297708,0.0003980792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.5133816,0.01215683,0.4281501,0.0006623195,0.0117874,0.0003497537,0.0003692617,0.001578963,0.004389476,0.00008907873,0.0005490345,0.02653605],"study_design_scores_gemma":[0.01676627,0.03982745,0.9363633,0.0000346104,0.004364827,0.0002211704,0.0002039591,0.00120042,0.0005072207,0.00004537085,0.0004169322,0.00004853629],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990665,0.0005049168,0.00002847442,0.00003150416,0.000009371625,0.00002417946,0.0001744125,0.000002633379,0.0001578914],"genre_scores_gemma":[0.9991651,0.0002197631,0.0001164272,0.00004079143,0.00002977679,0.00003302185,0.0002780439,0.000002687207,0.0001145113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002173253,"threshold_uncertainty_score":0.0100255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04003567002933493,"score_gpt":0.3368730361813623,"score_spread":0.2968373661520274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}