{"id":"W4210389977","doi":"10.1242/dmm.049258","title":"A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90","year":2022,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Queen Elizabeth Scholars; Lawson Foundation","keywords":"KEAP1; Yeast; Hsp90; Computational biology; Computer science; Biology; Genetics; Heat shock protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005998377,0.0001920752,0.0001337011,0.00004562167,0.0002284037,0.00002872805,0.0001788113,0.00003290839,0.00002402464],"category_scores_gemma":[0.0000107789,0.0001927756,0.00007017352,0.00005583973,0.00004860388,0.00001021858,0.000316067,0.0001273103,0.000001665718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002749266,"about_ca_system_score_gemma":0.0001137747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001121525,"about_ca_topic_score_gemma":0.00002133199,"domain_scores_codex":[0.9989278,0.0000270009,0.0001308174,0.0004932358,0.0001739455,0.0002472341],"domain_scores_gemma":[0.9992889,0.000004388058,0.00006750744,0.000339498,0.00006191368,0.0002378397],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004078858,0.0001847421,0.00001005466,0.00001684399,0.0000568329,0.000005210256,0.0001329708,0.04742683,0.9479128,0.003358892,0.0001126303,0.0003743345],"study_design_scores_gemma":[0.00266929,0.0006010613,0.00009387474,0.00003198326,0.0002134924,0.00006004908,0.0009473861,0.4670593,0.4720348,0.05417112,0.001069498,0.001048176],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5349522,0.0001903174,0.4637279,0.00008608227,0.00005453304,0.000208073,0.0004833547,0.00001825857,0.0002793522],"genre_scores_gemma":[0.9915336,0.00002248878,0.006979068,0.0004456804,0.0000537671,0.0002330652,0.0002587654,0.00004119752,0.0004323543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.475878,"threshold_uncertainty_score":0.7861159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01562183044822151,"score_gpt":0.2262799530045019,"score_spread":0.2106581225562804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}