{"id":"W4210389977","doi":"10.1242/dmm.049258","title":"A novel yeast model detects Nrf2 and Keap1 interactions with Hsp90","year":2022,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"Genomics, phytochemicals, and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Queen Elizabeth Scholars; Lawson Foundation","keywords":"KEAP1; Yeast; Hsp90; Computational biology; Computer science; Biology; Genetics; Heat shock protein; Gene; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001334443,0.0008013422,0.0005137417,0.0003629297,0.0005308806,0.0006337473,0.001005977,0.000630306,0.001770486],"category_scores_gemma":[0.0001421414,0.0002827365,0.0004810832,0.000392124,0.000330844,0.0004923152,0.0007097993,0.001014215,0.0007856734],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004863025,"about_ca_system_score_gemma":0.0003386937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002026852,"about_ca_topic_score_gemma":0.001736348,"domain_scores_codex":[0.9998478,0.0000264962,0.00001196768,0.00004759461,0.00004574079,0.00002041873],"domain_scores_gemma":[0.9999026,0.00001182756,0.00002087456,0.00001954415,0.00001659008,0.00002853091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002830995,0.0001549912,0.0006476728,0.0001142273,0.0000342675,0.0004882498,0.00006143396,0.00296746,0.9774035,0.01258707,0.001093019,0.004164861],"study_design_scores_gemma":[0.0002441511,0.001136556,0.003505834,0.00004928107,0.0001217825,0.001767746,0.000274607,0.07286619,0.8014388,0.01083132,0.1076248,0.0001387489],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7714972,0.004093028,0.1983968,0.001397902,0.0006235341,0.0002492809,0.005240579,0.002886789,0.01561484],"genre_scores_gemma":[0.9025431,0.002372026,0.07377963,0.0001764152,0.00002693782,0.0002730204,0.005559796,0.0003000499,0.01496908],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002026852,"threshold_uncertainty_score":0.005922914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01562183044822151,"score_gpt":0.2262799530045019,"score_spread":0.2106581225562804,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}