{"id":"W4210391000","doi":"10.1016/j.ebiom.2022.103833","title":"Seizure modulation by the gut microbiota and tryptophan-kynurenine metabolism in an animal model of infantile spasms","year":2022,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Gut microbiota and health","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland; Alberta Children's Hospital; University of Calgary","funders":"","keywords":"Kynurenine; Kynurenic acid; Kynurenine pathway; Indoleamine 2,3-dioxygenase; Ketogenic diet; Gut flora; Quinolinic acid; Pharmacology; Anticonvulsant; Metabolite; Biology; Medicine; Internal medicine; Epilepsy; Immunology; Tryptophan; Biochemistry; Antagonist","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002527856,0.000115978,0.0001819754,0.00007479893,0.00009759209,0.00000536725,0.0001499403,0.0000683598,0.00004211547],"category_scores_gemma":[0.000009276529,0.00008965981,0.00002631572,0.0001683909,0.000110703,0.000004561369,0.0001285492,0.000137424,3.038237e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001145917,"about_ca_system_score_gemma":0.00005648429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001161243,"about_ca_topic_score_gemma":0.00003859935,"domain_scores_codex":[0.999159,0.00006985904,0.0002353072,0.0002519106,0.0001026305,0.0001812892],"domain_scores_gemma":[0.9995724,0.000005550812,0.00009260786,0.0002444376,0.00003195238,0.00005308047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001347492,0.00007889139,0.001018711,0.00001753085,0.00001031404,7.47016e-7,0.000304162,0.0002344483,0.9930037,0.00004263487,0.004662586,0.0004915236],"study_design_scores_gemma":[0.01285158,0.00381397,0.3935691,0.00006631346,0.0001711301,0.0002694688,0.002019854,0.05567941,0.425092,0.0003913719,0.1049791,0.00109678],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960756,0.002089129,0.0001786348,0.001147836,0.00007583359,0.0002009394,0.0001803594,0.000005034306,0.00004666294],"genre_scores_gemma":[0.9979879,0.0001045445,0.0002946805,0.0005600462,0.00009849107,0.00001284344,0.0006260083,0.00001492351,0.0003005822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5679117,"threshold_uncertainty_score":0.3656221,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00838261668716221,"score_gpt":0.2551517250490383,"score_spread":0.2467691083618761,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}