{"id":"W4210399537","doi":"10.1111/liv.15175","title":"Patient‐specific genetic factors predict treatment failure in sofosbuvir‐treated patients with chronic hepatitis C","year":2022,"lang":"en","type":"article","venue":"Liver International","topic":"Hepatitis C virus research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Society of Intestinal Research; University of Calgary; Western University; University of Manitoba; BC Children's Hospital; University of British Columbia","funders":"","keywords":"Sofosbuvir; Medicine; Odds ratio; Internal medicine; Confidence interval; Hepatitis C virus; Pegylated interferon; Pharmacogenomics; Virus; Immunology; Ribavirin; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00003922278,0.0002085286,0.0002252503,0.0003963736,0.0001161819,0.00003234022,0.0001784149,0.00004789071,0.00833537],"category_scores_gemma":[0.00001915362,0.0001735133,0.00007646921,0.0002978123,0.00006729839,0.0001175362,0.0001439475,0.0002737293,0.00008446274],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002742872,"about_ca_system_score_gemma":0.0002026944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002971872,"about_ca_topic_score_gemma":0.002529178,"domain_scores_codex":[0.997697,0.0001070384,0.0003018121,0.0004162058,0.001143356,0.0003346058],"domain_scores_gemma":[0.9993104,0.0000568523,0.00008253153,0.0002597452,0.0001563943,0.0001340704],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002500579,0.0007714819,0.9765007,0.000008182052,0.0001643473,0.0003267229,0.0006250823,0.0002144085,0.00006134545,0.0000235471,0.001237579,0.01981654],"study_design_scores_gemma":[0.003505048,0.002621346,0.9190094,0.00003579577,0.00001839556,0.00001016159,0.00005014534,0.001141658,0.0002418622,0.000005575725,0.07320813,0.0001524649],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996276,0.0001266889,0.00002259184,0.0001551265,0.0002072766,0.0008833913,0.0005777762,0.0000526046,0.001698514],"genre_scores_gemma":[0.9969788,0.0001870302,0.0002262882,0.00005733698,0.00008570926,0.0003127232,0.001320294,0.00003978857,0.0007919832],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07197055,"threshold_uncertainty_score":0.9925712,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01476043140063459,"score_gpt":0.2462300790560023,"score_spread":0.2314696476553677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}