{"id":"W4210399537","doi":"10.1111/liv.15175","title":"Patient‐specific genetic factors predict treatment failure in sofosbuvir‐treated patients with chronic hepatitis C","year":2022,"lang":"en","type":"article","venue":"Liver International","topic":"Hepatitis C virus research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Society of Intestinal Research; University of Calgary; Western University; University of Manitoba; BC Children's Hospital; University of British Columbia","funders":"","keywords":"Sofosbuvir; Medicine; Odds ratio; Internal medicine; Confidence interval; Hepatitis C virus; Pegylated interferon; Pharmacogenomics; Virus; Immunology; Ribavirin; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005030276,0.0003835356,0.000293891,0.0003833336,0.000562929,0.0004477128,0.0003292839,0.0005886253,0.00222168],"category_scores_gemma":[0.001506069,0.0001613303,0.000427987,0.000605196,0.0003822525,0.0001587977,0.0002287548,0.0005068937,0.0001573588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004500832,"about_ca_system_score_gemma":0.0006221703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0131813,"about_ca_topic_score_gemma":0.01793217,"domain_scores_codex":[0.9997082,0.00007423094,0.00003188823,0.00008015332,0.00005246091,0.00005303812],"domain_scores_gemma":[0.9990421,0.0002734034,0.0004164636,0.00005698447,0.00007083646,0.0001401569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001843471,0.00001817415,0.9985383,0.000005681791,0.00005060754,0.00005256664,0.00003043865,0.00005245097,0.0003026597,0.00001000828,0.00005163075,0.0007031354],"study_design_scores_gemma":[0.00001376556,0.00006972603,0.99909,0.000005825457,0.00005376573,0.0002021977,0.00007683598,0.0003034847,0.00007864301,0.0000259943,0.00007685151,0.000003002635],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9995022,0.000136954,0.00004603314,0.0000360374,0.00000229137,0.000003847564,0.0001078192,0.00000152946,0.000163396],"genre_scores_gemma":[0.999756,0.00003131936,0.00004466215,0.00001560629,0.000003302586,0.00000177507,0.0001027768,8.37921e-7,0.00004360156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0131813,"threshold_uncertainty_score":0.02620918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01476043140063459,"score_gpt":0.2462300790560023,"score_spread":0.2314696476553677,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}