{"id":"W4210403562","doi":"10.1016/j.exphem.2020.09.115","title":"3102 – A SYNTHETIC LETHALITY APPROACH TO ERADICATE AML VIA SYNERGISTIC ACTIVATION OF PRO-APOPTOTIC P53 BY MDM2 AND BET INHIBITORS","year":2020,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"BRD4; Bromodomain; Cancer research; Mdm2; Synthetic lethality; Ubiquitin ligase; Puma; Wild type; Biology; BET inhibitor; Repressor; Myeloid leukemia; Psychological repression; Transcription factor; Ubiquitin; Chemistry; Gene; Mutant; Epigenetics; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008062795,0.0001872181,0.0002729284,0.00003903065,0.00006087199,0.00001129426,0.0001355579,0.0001574998,0.00002024288],"category_scores_gemma":[0.00009127496,0.0001841185,0.00005511926,0.0001129011,0.0001803097,0.000008759667,0.0001450643,0.00008467156,0.000008771387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001865974,"about_ca_system_score_gemma":0.00002639433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002658029,"about_ca_topic_score_gemma":3.565946e-7,"domain_scores_codex":[0.9987675,0.0001013195,0.0003213507,0.0004707602,0.000131874,0.0002071893],"domain_scores_gemma":[0.9994434,0.0000109539,0.0001275464,0.0002064467,0.00003010035,0.0001816198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001203084,0.0002201225,0.0001892536,0.0000696667,0.00003066169,7.263905e-7,0.0003099348,0.000005499447,0.9940144,0.001476825,0.003316838,0.0002457171],"study_design_scores_gemma":[0.000424188,0.0004161799,0.00003871885,0.00001568541,0.000008267935,0.00002212357,0.0002520167,0.000253167,0.9962959,0.00001949624,0.002070331,0.0001839683],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859818,0.001445107,0.0101987,0.000844494,0.00008492522,0.0005697468,0.00001845221,0.00002658814,0.0008301757],"genre_scores_gemma":[0.9977912,0.000006634407,0.001230846,0.0005857286,0.00006696471,0.000107876,0.0001405381,0.00002293867,0.00004723433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01180943,"threshold_uncertainty_score":0.7508135,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491333782361812,"score_gpt":0.2549239577877713,"score_spread":0.2400106199641532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}