{"id":"W4210403562","doi":"10.1016/j.exphem.2020.09.115","title":"3102 – A SYNTHETIC LETHALITY APPROACH TO ERADICATE AML VIA SYNERGISTIC ACTIVATION OF PRO-APOPTOTIC P53 BY MDM2 AND BET INHIBITORS","year":2020,"lang":"en","type":"article","venue":"Experimental Hematology","topic":"Protein Degradation and Inhibitors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"BRD4; Bromodomain; Cancer research; Mdm2; Synthetic lethality; Ubiquitin ligase; Puma; Wild type; Biology; BET inhibitor; Repressor; Myeloid leukemia; Psychological repression; Transcription factor; Ubiquitin; Chemistry; Gene; Mutant; Epigenetics; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000250365,0.0004225594,0.0003200028,0.0003175272,0.0002198154,0.0003693219,0.000351043,0.0003638694,0.002238893],"category_scores_gemma":[0.0001265742,0.0002016572,0.0002437866,0.0002256776,0.0002522762,0.0002916041,0.0002537532,0.0009494658,0.0005393881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003359869,"about_ca_system_score_gemma":0.0003282058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003510341,"about_ca_topic_score_gemma":0.0007289345,"domain_scores_codex":[0.9998068,0.00002789997,0.00001874794,0.00002990702,0.00007176593,0.00004488668],"domain_scores_gemma":[0.9999334,0.0000120886,0.00001373362,0.00001114361,0.000007497145,0.00002214144],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006015099,0.0001659004,0.0001573364,0.00004477959,0.00001835302,0.0001131237,0.00001831241,0.0004513642,0.9915876,0.001467347,0.0004095794,0.004964777],"study_design_scores_gemma":[0.0001015444,0.0005314536,0.0006509456,0.000004438745,0.00001377491,0.0004193321,0.00001541234,0.001589809,0.9881116,0.0001841815,0.00836825,0.000009168658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977143,0.001436738,0.01159624,0.0005633476,0.0001614263,0.000173476,0.00101408,0.0003683021,0.007543422],"genre_scores_gemma":[0.9869681,0.0007802508,0.005740529,0.0001018807,0.00002261536,0.0000942341,0.0007900647,0.00004599748,0.005456403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002238893,"threshold_uncertainty_score":0.00748986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01491333782361812,"score_gpt":0.2549239577877713,"score_spread":0.2400106199641532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}