{"id":"W4210407991","doi":"10.1016/j.molcel.2022.01.003","title":"ecDNAs personify cancer gangsters","year":2022,"lang":"en","type":"letter","venue":"Molecular Cell","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; Princess Margaret Cancer Centre","funders":"Canadian Institutes of Health Research","keywords":"Biology; Oncogene; Carcinogenesis; Extrachromosomal DNA; Transcription (linguistics); Genetics; Gene; Cancer; Cancer research; Cell cycle","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004135215,0.0009058258,0.001042876,0.0007113601,0.01003407,0.006481858,0.001936763,0.06960397,0.02563982],"category_scores_gemma":[0.02078528,0.0008870376,0.001349152,0.0004798851,0.002653401,0.003471421,0.00566722,0.04697248,0.01361524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004450315,"about_ca_system_score_gemma":0.009439388,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01506114,"about_ca_topic_score_gemma":0.03402236,"domain_scores_codex":[0.9964198,0.0004930283,0.0002293001,0.0003790185,0.001290347,0.001188644],"domain_scores_gemma":[0.9913168,0.002933405,0.0003558585,0.000428649,0.001401618,0.003563616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002835584,0.00002271962,0.0003539405,0.00001561361,0.000008703902,0.0008148489,0.00007139577,0.00002490618,0.0001159329,0.003340302,0.9905671,0.004636028],"study_design_scores_gemma":[0.00003685699,0.00002248105,0.0003905561,0.00005543495,0.00001032762,0.0005913163,0.0002564467,0.00008321763,0.0002046403,0.003166078,0.9951636,0.00001905745],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0007659722,0.002059879,0.0001923648,0.9381506,0.04297001,0.00003132489,0.00006789989,0.00007067889,0.01569124],"genre_scores_gemma":[0.003530188,0.0008675656,0.0001743303,0.9059628,0.01008641,0.00004593008,0.0000432702,0.00004076816,0.07924889],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.06960397,"threshold_uncertainty_score":0.08577377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006818385115012445,"score_gpt":0.2181749025159427,"score_spread":0.2113565174009303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}