{"id":"W4210408078","doi":"10.1139/cjpp-2021-0399","title":"Mechanisms of action of SGLT2 inhibitors and their beneficial effects on the cardiorenal axis","year":2022,"lang":"en","type":"review","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Heart failure; Cardiorenal syndrome; Diabetes mellitus; Adipokine; Renin–angiotensin system; Internal medicine; Kidney; Type 2 diabetes; Endocrinology; Pharmacology; Cardiology; Bioinformatics; Blood pressure; Insulin resistance; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004644766,0.000737568,0.00135708,0.001747758,0.0001908876,0.0007971134,0.0006932853,0.0008071963,0.002893557],"category_scores_gemma":[0.0005966102,0.0001856595,0.0006946943,0.001327369,0.0003292534,0.0007595092,0.0004115853,0.001448356,0.0008436076],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000483386,"about_ca_system_score_gemma":0.0008573973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001374371,"about_ca_topic_score_gemma":0.002824427,"domain_scores_codex":[0.9998504,0.00002377685,0.00003119768,0.00002276903,0.0000564547,0.00001532945],"domain_scores_gemma":[0.9997759,0.0001084939,0.0000405426,0.000004444937,0.00005406043,0.00001653004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002248059,0.0001030899,0.0003013568,0.02823863,0.0002389954,0.0002522518,0.00006299234,0.000352846,0.001665217,0.002548533,0.02064915,0.9453621],"study_design_scores_gemma":[0.000131542,0.0003891946,0.004337259,0.01144083,0.0006283814,0.002593782,0.0001035776,0.0002630189,0.001253287,0.002810056,0.9760039,0.0000452911],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000107978,0.999241,0.00004298062,0.000198769,0.00007855774,0.000002860371,0.00001507946,0.000003282899,0.0003095499],"genre_scores_gemma":[0.0006313994,0.998821,0.00009199129,0.000129533,0.00009798765,0.000005437612,0.00002157592,5.970924e-7,0.000200475],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002893557,"threshold_uncertainty_score":0.009679973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03099381702576596,"score_gpt":0.2991254289553311,"score_spread":0.2681316119295651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}