{"id":"W4210419497","doi":"10.21203/rs.3.rs-1296940/v1","title":"Inhibition of TGFβ-induced Fibroblast to Myofibroblast Transition by Conditioned Medium From Human Rhinovirus-infected Airway Epithelial Cells is Mediated by Prostaglandin E2","year":2022,"lang":"en","type":"preprint","venue":"Research Square","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; GlaxoSmithKline","keywords":"Myofibroblast; Fibroblast; Transforming growth factor; Rhinovirus; Respiratory epithelium; Extracellular matrix; Epithelium; Biology; Downregulation and upregulation; Immunology; Cell biology; Chemistry; Cell culture; Medicine; Pathology; Fibrosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003656826,0.0006784562,0.0005491643,0.0002950556,0.0001878003,0.0003068012,0.0002308914,0.0002363543,0.00197073],"category_scores_gemma":[0.0002352993,0.0001705929,0.0005210489,0.0001509056,0.00032395,0.0001474069,0.0003156276,0.0006548585,0.0004479862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001745115,"about_ca_system_score_gemma":0.0003211814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006399823,"about_ca_topic_score_gemma":0.0007812715,"domain_scores_codex":[0.999714,0.00007523398,0.00003748541,0.00003290804,0.00006903477,0.00007132092],"domain_scores_gemma":[0.9997939,0.0000853751,0.0000280339,0.00002386351,0.00002172735,0.00004711714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007599845,0.0001116414,0.0002094451,0.00008871365,0.000009245981,0.00008029835,0.00002412074,0.00004088145,0.9972253,0.000035094,0.00004922838,0.001366082],"study_design_scores_gemma":[0.0001104319,0.001696114,0.006592929,0.00002233118,0.00003063872,0.000205981,0.0000328723,0.0006443831,0.9891451,0.00003040846,0.001482613,0.00000606766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892453,0.005212076,0.002706527,0.0001567486,0.000161023,0.0001233086,0.0007106329,0.00006216723,0.001622326],"genre_scores_gemma":[0.9885682,0.002643039,0.004351641,0.0001085133,0.00008032587,0.0001648257,0.001815258,0.00001876411,0.002249466],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00197073,"threshold_uncertainty_score":0.006592751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02665067954993716,"score_gpt":0.3353611884008195,"score_spread":0.3087105088508823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}