{"id":"W4210420162","doi":"10.26685/urncst.290","title":"Using Prime Editing and Mesenchymal Stem Cell-Derived Exosomes to Treat Cystic Fibrosis: A Research Protocol","year":2022,"lang":"en","type":"article","venue":"Undergraduate Research in Natural and Clinical Science and Technology (URNCST) Journal","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Sport Centre Pacific","funders":"","keywords":"Cystic fibrosis; Mesenchymal stem cell; Cystic fibrosis transmembrane conductance regulator; Microvesicles; Lung; Stem cell; Exosome; Pathology; Cancer research; Medicine; Biology; Cell biology; microRNA; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002490005,0.001244014,0.001354135,0.0009501862,0.001253518,0.0008472452,0.001309437,0.001755108,0.02027837],"category_scores_gemma":[0.001369868,0.0004102437,0.001641409,0.0006073316,0.0006484461,0.0008870799,0.001020506,0.001679388,0.005875917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005923198,"about_ca_system_score_gemma":0.002238951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000334118,"about_ca_topic_score_gemma":0.0004365154,"domain_scores_codex":[0.9985381,0.0003559261,0.0002411217,0.0002710267,0.0004355428,0.0001581506],"domain_scores_gemma":[0.9992734,0.0001505379,0.00008916975,0.0001540986,0.0002121383,0.0001206586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01007773,0.0042505,0.0008848253,0.0137005,0.0001809393,0.002758123,0.0006076284,0.001222794,0.7691439,0.0115873,0.03944739,0.1461384],"study_design_scores_gemma":[0.002594776,0.01885651,0.002078329,0.00120973,0.000594857,0.00378503,0.0002386753,0.0009223682,0.4212079,0.002052565,0.5462861,0.0001731649],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.226425,0.06847493,0.2275324,0.005928182,0.01006175,0.3461838,0.02761083,0.003232502,0.08455066],"genre_scores_gemma":[0.1822502,0.07365737,0.2022639,0.003957463,0.001597681,0.4135474,0.03284649,0.0004308251,0.08944871],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02027837,"threshold_uncertainty_score":0.06783789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07827996372117255,"score_gpt":0.4402841007302178,"score_spread":0.3620041370090452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}