{"id":"W4210423203","doi":"10.1097/01.hs9.0000821540.81071.fa","title":"P112: ENERGIZE AND ENERGIZE-T: TWO PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDIES OF MITAPIVAT IN ADULTS WITH NON--TRANSFUSION-DEPENDENT OR TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA","year":2022,"lang":"en","type":"article","venue":"HemaSphere","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Thalassemia; Medicine; Internal medicine; Placebo; Ineffective erythropoiesis; Blood transfusion; Gastroenterology; Anemia; Erythropoiesis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001436829,0.0007614738,0.003186052,0.0003195857,0.0004014926,0.00002889831,0.0002665056,0.0002658063,0.002661691],"category_scores_gemma":[0.0001429085,0.0004477361,0.0004559146,0.0007810865,0.0003947003,0.0001670529,0.0001738458,0.0009279703,0.000006001625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002199446,"about_ca_system_score_gemma":0.0006076231,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001302052,"about_ca_topic_score_gemma":0.003473463,"domain_scores_codex":[0.9948342,0.0004481159,0.001628539,0.001019557,0.001303964,0.000765633],"domain_scores_gemma":[0.9973113,0.001028486,0.0004260305,0.0006108002,0.0002587814,0.0003645923],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9756203,0.002271375,0.0006695846,0.0009295816,0.002024617,0.001851224,0.007231824,0.001750552,0.002939809,0.000121214,0.0003627428,0.004227153],"study_design_scores_gemma":[0.9549401,0.002740188,0.0000126789,0.001179905,0.001722309,0.0005879888,0.03169456,0.001302507,0.004820388,0.00003725612,0.0003739392,0.0005882134],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781227,0.01032772,0.0001643538,0.001480606,0.0003800159,0.006550453,0.00005302112,0.0000936443,0.002827489],"genre_scores_gemma":[0.9738699,0.0169187,0.0004538343,0.0002794272,0.00009835578,0.002226579,0.00005624349,0.000120105,0.005976852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02446274,"threshold_uncertainty_score":0.9997975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872629741786702,"score_gpt":0.2970107363367706,"score_spread":0.2782844389189036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}