{"id":"W4210423203","doi":"10.1097/01.hs9.0000821540.81071.fa","title":"P112: ENERGIZE AND ENERGIZE-T: TWO PHASE 3, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDIES OF MITAPIVAT IN ADULTS WITH NON--TRANSFUSION-DEPENDENT OR TRANSFUSION-DEPENDENT ALPHA- OR BETA-THALASSEMIA","year":2022,"lang":"en","type":"article","venue":"HemaSphere","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Thalassemia; Medicine; Internal medicine; Placebo; Ineffective erythropoiesis; Blood transfusion; Gastroenterology; Anemia; Erythropoiesis; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0033226,0.002850816,0.003553522,0.0007195896,0.0008832722,0.001831046,0.001457748,0.004215702,0.01130883],"category_scores_gemma":[0.003314278,0.001132278,0.003119728,0.0005110141,0.00151737,0.00174027,0.0005669443,0.004723375,0.001519786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007601819,"about_ca_system_score_gemma":0.001580868,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006713376,"about_ca_topic_score_gemma":0.001541343,"domain_scores_codex":[0.9986903,0.0006576016,0.0001050889,0.0002669352,0.0001351277,0.0001448674],"domain_scores_gemma":[0.9983551,0.0004656357,0.000421576,0.0001210558,0.0001609401,0.0004756915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9680976,0.01142093,0.0003210749,0.001559039,0.001435829,0.00005378201,0.00007178327,0.0001776309,0.003739691,0.0001829161,0.001581389,0.01135828],"study_design_scores_gemma":[0.9676589,0.03054939,0.0004528892,0.00003120453,0.0002696025,0.00001924879,0.000009996115,0.00009968266,0.0002491714,0.00007861444,0.0005699164,0.00001142018],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9112913,0.01513978,0.003845432,0.004674738,0.003017123,0.04838911,0.005701447,0.0008094272,0.007131589],"genre_scores_gemma":[0.9092797,0.007284639,0.007961903,0.007379201,0.001614714,0.05471313,0.003106772,0.0001196388,0.008540246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01130883,"threshold_uncertainty_score":0.03783178,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872629741786702,"score_gpt":0.2970107363367706,"score_spread":0.2782844389189036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}