{"id":"W4210424506","doi":"10.2196/preprints.11545","title":"TheraSphere Yttrium-90 Glass Microspheres Combined With Chemotherapy Versus Chemotherapy Alone in Second-Line Treatment of Patients With Metastatic Colorectal Carcinoma of the Liver: Protocol for the EPOCH Phase 3 Randomized Clinical Trial (Preprint)","year":2018,"lang":"en","type":"preprint","venue":"","topic":"Hepatocellular Carcinoma Treatment and Prognosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Oxaliplatin; Irinotecan; Regimen; Clinical endpoint; Colorectal cancer; Internal medicine; Chemotherapy; Oncology; Chemotherapy regimen; Randomized controlled trial; Progression-free survival; Cancer; Surgery","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007900027,0.003402635,0.003835813,0.0007935192,0.001055312,0.001824011,0.001854659,0.003080464,0.02371037],"category_scores_gemma":[0.005339836,0.001282686,0.003144668,0.001159135,0.001313158,0.001293494,0.000979549,0.004106043,0.003333997],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002066279,"about_ca_system_score_gemma":0.005938541,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001594698,"about_ca_topic_score_gemma":0.003932819,"domain_scores_codex":[0.9969581,0.00194986,0.00021998,0.000259483,0.0002377114,0.0003748337],"domain_scores_gemma":[0.9976112,0.0004414787,0.0007012577,0.0002682655,0.0003368029,0.0006409524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9856443,0.004522661,0.000239723,0.0007572054,0.0004496753,0.00002885696,0.00002912125,0.0003827268,0.001122563,0.0001834222,0.002846641,0.003793125],"study_design_scores_gemma":[0.9678753,0.0263666,0.0006600168,0.00009208441,0.0003040544,0.00001749954,0.00001633445,0.0003867727,0.0002809526,0.0002415099,0.003742104,0.00001675572],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.1515904,0.002871892,0.003654357,0.002299202,0.002399865,0.8117039,0.01573257,0.0004555309,0.009292165],"genre_scores_gemma":[0.116985,0.002197932,0.008178578,0.003365296,0.0007190271,0.8556336,0.005024848,0.00006576286,0.00783009],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.02371037,"threshold_uncertainty_score":0.07931912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09265475795610757,"score_gpt":0.3556980734517257,"score_spread":0.2630433154956181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}