{"id":"W4210426744","doi":"10.3390/life12020211","title":"Analysis of Signal Transduction Pathways Downstream M2 Receptor Activation: Effects on Schwann Cell Migration and Morphology","year":2022,"lang":"en","type":"article","venue":"Life","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Cell biology; Signal transduction; mTORC1; PI3K/AKT/mTOR pathway; Protein kinase B; Functional selectivity; Biology; Receptor; Chemistry; G protein-coupled receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578204,0.0003447483,0.0002395493,0.0002620434,0.0002093876,0.0001838266,0.0001102767,0.0002631036,0.001692676],"category_scores_gemma":[0.00006235616,0.00007706288,0.0003295863,0.000236275,0.0001548807,0.0001704586,0.0001081249,0.0004592028,0.000458203],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001857985,"about_ca_system_score_gemma":0.0001535847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003303366,"about_ca_topic_score_gemma":0.0004959322,"domain_scores_codex":[0.9998568,0.00001677676,0.00001233504,0.00002720175,0.00003833301,0.00004853386],"domain_scores_gemma":[0.99992,0.00001240907,0.00002025575,0.000006268205,0.00002243109,0.00001868936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001860559,0.00003712526,0.0003146247,0.00006794258,0.0000047939,0.00004389251,0.00001855618,0.00002153271,0.9983562,0.00002261831,0.000021752,0.0009050776],"study_design_scores_gemma":[0.00001423832,0.0005237606,0.01610152,0.000008164458,0.00002402205,0.0002140678,0.00007609898,0.000450738,0.9813983,0.00002761042,0.001156008,0.000005467611],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937701,0.002001976,0.002180233,0.00005061874,0.00002627784,0.00003225415,0.0006020516,0.00003598805,0.001300521],"genre_scores_gemma":[0.9883873,0.002611264,0.004660478,0.00006101972,0.00002173925,0.0001714593,0.0009862793,0.00002138455,0.003078999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001692676,"threshold_uncertainty_score":0.00566256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901436988529049,"score_gpt":0.2280963052546746,"score_spread":0.2090819353693841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}