{"id":"W4210426744","doi":"10.3390/life12020211","title":"Analysis of Signal Transduction Pathways Downstream M2 Receptor Activation: Effects on Schwann Cell Migration and Morphology","year":2022,"lang":"en","type":"article","venue":"Life","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Cell biology; Signal transduction; mTORC1; PI3K/AKT/mTOR pathway; Protein kinase B; Functional selectivity; Biology; Receptor; Chemistry; G protein-coupled receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000132472,0.00008371611,0.0001485262,0.000245889,0.0002403578,0.00001376025,0.0000647104,0.00004263614,0.000349517],"category_scores_gemma":[0.00004976419,0.00007824991,0.00006901041,0.0006832947,0.00004216771,0.0001161463,0.00001592004,0.0001236525,0.000004247825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002539338,"about_ca_system_score_gemma":0.00002609157,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002113382,"about_ca_topic_score_gemma":0.000003959895,"domain_scores_codex":[0.9989054,0.0003274613,0.0001729931,0.000279386,0.0002214062,0.00009341561],"domain_scores_gemma":[0.9995313,0.0001592777,0.0001240325,0.0001239554,0.00001835131,0.00004310688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000126648,0.0001190774,0.0004540358,0.00001465281,0.00001759364,0.000001434011,0.0003077751,0.006435064,0.9897318,0.0005870617,0.0002426204,0.001962235],"study_design_scores_gemma":[0.00025641,0.0005269546,0.001416714,0.000002684176,0.0000813056,0.0000013122,0.00005806721,0.00248218,0.9945073,0.00003592951,0.0005541458,0.00007702521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980173,0.00001583034,0.0006406333,0.0006360348,0.0002465956,0.0001608989,0.00004797917,0.00002878398,0.000205918],"genre_scores_gemma":[0.9991517,0.00001239805,0.00005321807,0.0004237945,0.000101581,0.00004339133,0.00006727922,0.0000062763,0.0001403326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004775471,"threshold_uncertainty_score":0.3826966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901436988529049,"score_gpt":0.2280963052546746,"score_spread":0.2090819353693841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}