{"id":"W4210446151","doi":"10.1101/2022.02.01.478160","title":"Profilin 1 deficiency drives mitotic defects and impairs genome stability","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze; Associazione Italiana per la Ricerca sul Cancro; Fondazione Umberto Veronesi","keywords":"Cytokinesis; Profilin; Mitosis; Anaphase; Cell biology; Biology; Genome instability; Cell division; Genetics; Actin cytoskeleton; Cell; Cell cycle; Cytoskeleton; DNA damage; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001169618,0.0004417074,0.0002432734,0.0004425021,0.0001453703,0.0002784206,0.0002160759,0.0003410066,0.002174801],"category_scores_gemma":[0.00009545132,0.0002117202,0.0001471336,0.0001979721,0.0002377042,0.000129743,0.0003186338,0.0004351541,0.0006789975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002548076,"about_ca_system_score_gemma":0.0001376734,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004632086,"about_ca_topic_score_gemma":0.000759692,"domain_scores_codex":[0.9998473,0.00002182675,0.00001730406,0.00003535405,0.00004941796,0.00002881112],"domain_scores_gemma":[0.9998224,0.00003127133,0.00006656797,0.00001952716,0.000009548648,0.00005063321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002513058,0.000007349899,0.0000927324,0.00001221365,0.00000140687,0.00006592653,0.000005549366,0.00004160433,0.999261,0.00008573842,0.00002365805,0.000377649],"study_design_scores_gemma":[0.00000992371,0.00006966336,0.005624549,0.000005749936,0.000006549846,0.0005433007,0.0000184176,0.001150875,0.9904033,0.00007193835,0.002091463,0.000004299289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933438,0.0007609384,0.00267208,0.00007306708,0.0000225736,0.00001484187,0.0009325866,0.000177944,0.00200206],"genre_scores_gemma":[0.991688,0.0004958273,0.00148259,0.0000274944,0.000006620402,0.00001718691,0.0006622642,0.00006473697,0.005555318],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002174801,"threshold_uncertainty_score":0.007275403,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01095077661445248,"score_gpt":0.2171360600224213,"score_spread":0.2061852834079688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}