{"id":"W4210447725","doi":"10.1053/j.gastro.2022.01.044","title":"Higher vs Standard Adalimumab Induction Dosing Regimens and Two Maintenance Strategies: Randomized SERENE CD Trial Results","year":2022,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Janssen Pharmaceuticals; Sandoz; Merck Sharp and Dohme; Johnson and Johnson; Genentech; Active Biotech; Ipsen; Tillotts Pharma; Vifor Pharma; Novo Nordisk; UCB; Otsuka America; Ferring Pharmaceuticals; Arrien Pharmaceuticals; Gilead Sciences; Medtronic; Roche; Takeda Pharmaceutical Company; Amgen; Boehringer Ingelheim; Schering-Plough; AbbVie; Sanofi; MedImmune; GlaxoSmithKline; Merck; Shire; Chiesi Farmaceutici; Bristol-Myers Squibb; Allergan; AstraZeneca; Seres Therapeutics; Pfizer","keywords":"Dosing; Adalimumab; Medicine; Randomized controlled trial; Internal medicine; Tumor necrosis factor alpha","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006564116,0.002034411,0.003478295,0.0006054773,0.0005666394,0.001985582,0.001201292,0.002791172,0.009292749],"category_scores_gemma":[0.004593879,0.0007611285,0.003697365,0.0004857449,0.001864594,0.002360946,0.0009099299,0.004052167,0.0009802791],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008688614,"about_ca_system_score_gemma":0.0009808602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004572414,"about_ca_topic_score_gemma":0.001098182,"domain_scores_codex":[0.9966868,0.002168931,0.000246254,0.0004206386,0.0002001203,0.0002773484],"domain_scores_gemma":[0.9967228,0.001388489,0.0006924673,0.0003635593,0.0001851592,0.0006475652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9908118,0.003098458,0.0003008151,0.0002126589,0.0007071739,0.00001493191,0.00002410827,0.0001044272,0.0005541859,0.00008280839,0.000273352,0.003815376],"study_design_scores_gemma":[0.9643986,0.03294148,0.0009174458,0.00003224796,0.0007435196,0.00002094851,0.00001675792,0.000217236,0.0001589011,0.0001491951,0.000389553,0.00001426056],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774175,0.008942491,0.001214813,0.001456127,0.0009654494,0.003999582,0.001346856,0.0001545641,0.004502683],"genre_scores_gemma":[0.9810432,0.003178787,0.002419279,0.001987383,0.001191328,0.004046344,0.00195499,0.00003824573,0.004140479],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009292749,"threshold_uncertainty_score":0.03471476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008478938493841409,"score_gpt":0.244550064538595,"score_spread":0.2360711260447536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}