{"id":"W4210447725","doi":"10.1053/j.gastro.2022.01.044","title":"Higher vs Standard Adalimumab Induction Dosing Regimens and Two Maintenance Strategies: Randomized SERENE CD Trial Results","year":2022,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":85,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Janssen Pharmaceuticals; Sandoz; Merck Sharp and Dohme; Johnson and Johnson; Genentech; Active Biotech; Ipsen; Tillotts Pharma; Vifor Pharma; Novo Nordisk; UCB; Otsuka America; Ferring Pharmaceuticals; Arrien Pharmaceuticals; Gilead Sciences; Medtronic; Roche; Takeda Pharmaceutical Company; Amgen; Boehringer Ingelheim; Schering-Plough; AbbVie; Sanofi; MedImmune; GlaxoSmithKline; Merck; Shire; Chiesi Farmaceutici; Bristol-Myers Squibb; Allergan; AstraZeneca; Seres Therapeutics; Pfizer","keywords":"Dosing; Adalimumab; Medicine; Randomized controlled trial; Internal medicine; Tumor necrosis factor alpha","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008359468,0.0002102677,0.0003658177,0.00006779125,0.0002127196,0.00003836848,0.0001641504,0.00007761496,0.00007485138],"category_scores_gemma":[0.00007398173,0.0002054368,0.0001279239,0.00004217997,0.00024824,0.00001110641,0.0002630906,0.0002090022,0.000001989658],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005873469,"about_ca_system_score_gemma":0.0001055058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002892383,"about_ca_topic_score_gemma":0.00008991379,"domain_scores_codex":[0.9975516,0.0008875707,0.0004313981,0.000524355,0.0001787614,0.0004263449],"domain_scores_gemma":[0.9991807,0.00002016823,0.0002544197,0.0003690631,0.00007104346,0.0001045868],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9842823,0.00006087032,0.0003345907,0.00001009675,0.0001373194,0.00008114109,0.00007584568,0.0004812132,0.01023279,0.0002931487,0.003923321,0.00008736546],"study_design_scores_gemma":[0.97787,0.003046544,0.003456776,0.00001062426,0.0001204839,0.0001415587,0.0003039015,0.00008061793,0.0003895944,0.0005900667,0.01376258,0.000227224],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963703,0.0000611813,0.0005586679,0.0009128664,0.0009032394,0.000643119,0.000160783,0.00002960206,0.0003602672],"genre_scores_gemma":[0.9975385,0.00003555102,0.000303347,0.0008292521,0.0003983465,0.0002043367,0.0002391707,0.00002791002,0.0004235531],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009843196,"threshold_uncertainty_score":0.8377471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008478938493841409,"score_gpt":0.244550064538595,"score_spread":0.2360711260447536,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}