{"id":"W4210448189","doi":"10.1093/hmg/ddac019","title":"Association with HLA-DRβ1 position 37 distinguishes juvenile dermatomyositis from adult-onset myositis","year":2022,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Inflammatory Myopathies and Dermatomyositis","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Calgary; Izaak Walton Killam Health Centre; Dalhousie University; Hospital for Sick Children; Institute of Infection and Immunity","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; Medical Research Council; Versus Arthritis; National Institute for Health and Care Research; Action Medical Research; Medical Research Council Canada; Wellcome Trust","keywords":"Juvenile dermatomyositis; Biology; Dermatomyositis; Myositis; Juvenile; Human leukocyte antigen; Genetics; Immunology; Pathology; Anatomy; Antigen; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001573152,0.0003131171,0.0004320105,0.0001163307,0.0007958988,0.0001112705,0.0001851879,0.000131549,0.0007836227],"category_scores_gemma":[0.00004144859,0.0003469589,0.0001714791,0.0002619727,0.00006346032,0.00005708573,0.0001816778,0.0004488853,0.00005969487],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004959192,"about_ca_system_score_gemma":0.00013058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000212276,"about_ca_topic_score_gemma":0.00005058151,"domain_scores_codex":[0.9972975,0.000242092,0.0004993008,0.0004808066,0.0009969641,0.0004833598],"domain_scores_gemma":[0.9985405,0.00004977371,0.0003427118,0.0005491632,0.0003158038,0.0002020523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006138814,0.0008900036,0.6807886,0.0003713976,0.00147324,0.01703977,0.004445527,0.0006321277,0.1912944,0.002096405,0.09810857,0.00224611],"study_design_scores_gemma":[0.009110535,0.002224203,0.8028662,0.0004882027,0.002105906,0.00395862,0.001303198,0.002148496,0.1218839,0.00171881,0.05020588,0.001986162],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931981,0.0009833154,0.0009819353,0.0009241899,0.0002017513,0.0005160604,0.0003604125,0.0001974378,0.002636793],"genre_scores_gemma":[0.9912329,0.00004431726,0.002925551,0.003282763,0.0002112479,0.0001522464,0.00168429,0.0001010648,0.00036557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1220775,"threshold_uncertainty_score":0.9998983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005240613345429813,"score_gpt":0.2216507197913316,"score_spread":0.2164101064459018,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}