{"id":"W4210449541","doi":"10.1002/hbm.25727","title":"Data‐driven staging of genetic frontotemporal dementia using multi‐modal <scp>MRI</scp>","year":2022,"lang":"en","type":"article","venue":"Human Brain Mapping","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; Toronto Western Hospital; Sunnybrook Health Science Centre; Health Sciences Centre; Douglas Mental Health University Institute; McGill University; Université Laval; Montreal Neurological Institute and Hospital","funders":"Medical Research Council; Fonds de Recherche du Québec - Santé; Health Canada; Demensfonden; Stichting Dioraphte; Vetenskapsrådet; Hartstichting; Brain Research UK; Deutsche Forschungsgemeinschaft; National Institute for Health and Care Research; Alzheimer Nederland; Karolinska Institutet; EU Joint Programme – Neurodegenerative Disease Research; Wellcome Trust; Institute on the Environment, University of Minnesota; European Commission; Stockholms Läns Landsting; Fondation Brain Canada; ZonMw; Canada Foundation for Innovation; Alzheimer's Association","keywords":"Frontotemporal dementia; Fractional anisotropy; Dementia; Neuropsychology; Population; Psychology; Diffusion MRI; White matter; Disease; Neuroimaging; Medicine; Pathology; Psychiatry; Magnetic resonance imaging; Radiology; Cognition","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001293608,0.0003730194,0.0003010948,0.0008922657,0.0002366549,0.0005369103,0.0003467828,0.0003164815,0.0005942692],"category_scores_gemma":[0.004210581,0.0001243049,0.0003640646,0.0004521656,0.0001898823,0.0004108058,0.0004019427,0.0003428326,0.0001708378],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004966536,"about_ca_system_score_gemma":0.0005271703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006678405,"about_ca_topic_score_gemma":0.01465066,"domain_scores_codex":[0.9996694,0.0001294963,0.00002727268,0.000106158,0.00004823263,0.00001941738],"domain_scores_gemma":[0.9984889,0.0007332331,0.0003544601,0.0001905783,0.0001614065,0.00007142495],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001243664,0.0003010186,0.637928,0.0001943009,0.0008089541,0.0005481344,0.0003179144,0.05916844,0.04067732,0.001506806,0.001809918,0.2554955],"study_design_scores_gemma":[0.00007052999,0.0004435818,0.4528638,0.00005776723,0.0001686881,0.001363318,0.0001786054,0.5114434,0.02488413,0.006421884,0.002018004,0.00008634101],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8943388,0.0003622762,0.1008636,0.0002258226,0.00001827577,0.00007779491,0.002814857,0.0005351891,0.0007633523],"genre_scores_gemma":[0.9554026,0.00009252221,0.04168846,0.00003136469,0.00001227847,0.00004081693,0.002435569,0.00003388538,0.0002623928],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006678405,"threshold_uncertainty_score":0.01327908,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1029520018621268,"score_gpt":0.3560532164611983,"score_spread":0.2531012145990715,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}