{"id":"W4210458772","doi":"10.1016/j.scr.2022.102689","title":"Generation of a patient-derived induced pluripotent cell line (SCTCi016-A) carrying a homozygous variant in RPE65","year":2022,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Foundation Fighting Blindness","keywords":"Biology; Induced pluripotent stem cell; SOX2; RPE65; KLF4; Peripheral blood mononuclear cell; Cell culture; Gene; LIN28; Molecular biology; Cell biology; Cancer research; Genetics; Genetic enhancement; Embryonic stem cell","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002886161,0.0002108988,0.0002933865,0.0003856042,0.0002715308,0.0002871685,0.0002358937,0.0003974881,0.003466015],"category_scores_gemma":[0.0003112784,0.0001397196,0.0002788008,0.0004503776,0.0001563959,0.0000886496,0.0002582577,0.0006816335,0.001855872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001262093,"about_ca_system_score_gemma":0.0002573757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005848383,"about_ca_topic_score_gemma":0.0007947956,"domain_scores_codex":[0.9997839,0.00002050139,0.00005400027,0.00004197515,0.00007768892,0.00002192145],"domain_scores_gemma":[0.9998056,0.0000323591,0.00002168256,0.00006297382,0.00003537801,0.00004198351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001127631,0.0001088525,0.001986017,0.00006907646,0.00001586169,0.001712793,0.000116173,0.0001677254,0.9878313,0.0006102392,0.0008780511,0.006391133],"study_design_scores_gemma":[0.0001916621,0.001109951,0.01929711,0.00008968497,0.0001204094,0.02233196,0.0001705021,0.003692405,0.9109263,0.000278821,0.04175629,0.00003487017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9609053,0.001081792,0.01701558,0.0003576486,0.0002457509,0.0009405293,0.00824189,0.0004385719,0.01077293],"genre_scores_gemma":[0.9473152,0.001354056,0.02314534,0.0002690347,0.00005189898,0.00062668,0.01451153,0.0001086495,0.01261753],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003466015,"threshold_uncertainty_score":0.01159495,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0680124627639353,"score_gpt":0.3046979385624564,"score_spread":0.2366854757985211,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}