{"id":"W4210459027","doi":"10.1039/d1ob02468j","title":"A dual therapeutic system based on corrole-siRNA conjugates","year":2022,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"Porphyrin and Phthalocyanine Chemistry","field":"Materials Science","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Corrole; Gene knockdown; Small interfering RNA; Gene silencing; Chemistry; Photosensitizer; RNA interference; Photodynamic therapy; Biophysics; Cell biology; Transfection; Gene; Biochemistry; Photochemistry; RNA; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001973605,0.0004749942,0.0003812719,0.0002403583,0.0002003557,0.0002937714,0.0002797076,0.0005266701,0.00178166],"category_scores_gemma":[0.0001348593,0.0002347035,0.0002222347,0.000112833,0.0002101685,0.0002713882,0.000248776,0.0004720236,0.0005300071],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003925841,"about_ca_system_score_gemma":0.0002454387,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003950293,"about_ca_topic_score_gemma":0.000755946,"domain_scores_codex":[0.9998605,0.00002241942,0.00001146172,0.00005256306,0.00002746563,0.00002560071],"domain_scores_gemma":[0.9999273,0.00001898121,0.00001589875,0.000008915594,0.00001131448,0.00001768929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005970376,0.00001673432,0.00002816462,0.0000594516,0.000007298552,0.00003245427,0.000007524124,0.00005384616,0.9974985,0.000129475,0.00006582004,0.002041055],"study_design_scores_gemma":[0.00001200369,0.0002380254,0.0001805923,0.000002511621,0.00001363488,0.0001274394,0.000002627409,0.0003984092,0.996967,0.00001088727,0.002042688,0.000004144741],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9664923,0.003617276,0.02255875,0.0002491825,0.0001308704,0.0002407383,0.0002870556,0.0005971992,0.005826507],"genre_scores_gemma":[0.9780619,0.001230654,0.01301103,0.0001713547,0.00002123141,0.0001664707,0.0002893518,0.0000440425,0.007004042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00178166,"threshold_uncertainty_score":0.005960286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007076877653494564,"score_gpt":0.2033563133679657,"score_spread":0.1962794357144711,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}