{"id":"W4210461470","doi":"10.1155/2022/2673396","title":"Computational Insights in DNA Methylation: Catalytic and Mechanistic Elucidations for Forming 3-Methyl Cytosine","year":2022,"lang":"en","type":"article","venue":"Journal of Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"University of Jordan; Compute Canada","keywords":"Chemistry; Methylation; Methyltransferase; DNA methylation; Epigenetics; Cytosine; DNA; CpG site; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003481138,0.0000823425,0.000131639,0.00005713444,0.0001182643,0.00001675614,0.00009504986,0.0000512368,0.00001616247],"category_scores_gemma":[0.0001618837,0.00008660027,0.00006005705,0.00009707308,0.00002137004,0.000007620667,0.00006260601,0.0001109476,1.064518e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000433288,"about_ca_system_score_gemma":0.0001303225,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001265357,"about_ca_topic_score_gemma":0.000001825931,"domain_scores_codex":[0.9992366,0.00002633266,0.0003465873,0.0001290832,0.0001646569,0.00009670025],"domain_scores_gemma":[0.9994058,0.00006456241,0.0002542106,0.00008335393,0.000139815,0.00005223072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006812075,0.00005289572,0.0001927561,0.00003704141,0.00002850692,0.000002921688,0.00008640997,0.01132106,0.9864221,0.00008830072,0.00005570587,0.001644166],"study_design_scores_gemma":[0.001321604,0.0002377921,0.0007263507,0.00001398069,0.00004048415,0.00006042304,0.0002192392,0.003085966,0.9750525,0.01092162,0.008162645,0.0001574178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.96628,0.002059061,0.03107019,0.0001869056,0.00008185673,0.00009785561,0.00002226675,0.000001823563,0.0002000713],"genre_scores_gemma":[0.9954422,0.00005867986,0.004019974,0.00003649839,0.0001548362,0.0000143196,0.0001524276,0.00001156715,0.0001094821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02916225,"threshold_uncertainty_score":0.3531457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107856517982262,"score_gpt":0.2595151077752808,"score_spread":0.2487294559770546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}