{"id":"W4210461470","doi":"10.1155/2022/2673396","title":"Computational Insights in DNA Methylation: Catalytic and Mechanistic Elucidations for Forming 3-Methyl Cytosine","year":2022,"lang":"en","type":"article","venue":"Journal of Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Memorial University of Newfoundland","funders":"University of Jordan; Compute Canada","keywords":"Chemistry; Methylation; Methyltransferase; DNA methylation; Epigenetics; Cytosine; DNA; CpG site; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006525254,0.0009554091,0.001414009,0.0007190093,0.001081723,0.001110702,0.001764056,0.002274552,0.004673315],"category_scores_gemma":[0.001479295,0.0005276602,0.001145966,0.0006694579,0.0008999406,0.001320608,0.0008493942,0.001185502,0.0004547481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009907963,"about_ca_system_score_gemma":0.001695461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008197155,"about_ca_topic_score_gemma":0.006876505,"domain_scores_codex":[0.9997891,0.00006589969,0.000007119373,0.00002452257,0.00005167477,0.00006168885],"domain_scores_gemma":[0.9995789,0.0002646493,0.00002404041,0.0000414902,0.0000530304,0.00003791304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001292556,0.0001339516,0.001389906,0.0003841156,0.00006480344,0.0003104081,0.0001049425,0.9299288,0.00239889,0.05777059,0.001381576,0.006002665],"study_design_scores_gemma":[0.0000280749,0.00002825953,0.0001855063,0.00001553577,0.0000136793,0.00001717507,0.00003626063,0.9904851,0.0002442953,0.008362064,0.0005764621,0.00000752771],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7279617,0.005781845,0.1750085,0.00550125,0.0004904005,0.0002284377,0.002297625,0.0005790364,0.08215122],"genre_scores_gemma":[0.9657362,0.001787737,0.02791672,0.0004457183,0.00008670268,0.0003285295,0.0008591486,0.0001235841,0.002715701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008197155,"threshold_uncertainty_score":0.01629889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107856517982262,"score_gpt":0.2595151077752808,"score_spread":0.2487294559770546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}