{"id":"W4210470119","doi":"10.1101/2022.01.26.468593","title":"VEGF-C expression in TAMs rewires the metastatic fate of breast cancer cells","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fondazione Regionale per la Ricerca Biomedica; Svenska Sällskapet för Medicinsk Forskning; Cancerfonden","keywords":"Lymphangiogenesis; Metastasis; Breast cancer; Medicine; Cancer research; Lymph node; Lymph; Cancer cell; Cancer; Tumor microenvironment; Circulating tumor cell; Vascular endothelial growth factor C; Angiogenesis; Podoplanin; Primary tumor; Lymphatic system; Pathology; Vascular endothelial growth factor; VEGF receptors; Internal medicine; Vascular endothelial growth factor A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006309866,0.0004216696,0.0008512134,0.0002650214,0.0001025453,0.00004919085,0.0004641607,0.0001515656,0.0006284213],"category_scores_gemma":[0.0001179073,0.0003073498,0.0002196215,0.0005302118,0.000132875,0.00007481686,0.000536716,0.0002110685,0.00001407016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003939287,"about_ca_system_score_gemma":0.001355606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004782704,"about_ca_topic_score_gemma":0.000005324331,"domain_scores_codex":[0.9971286,0.0003323289,0.0007544351,0.0006714397,0.0007091953,0.0004039907],"domain_scores_gemma":[0.9974244,0.0001509606,0.0005896191,0.00135741,0.0002575366,0.0002201094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002666992,0.000532301,0.06603346,0.003208176,0.0002537928,0.0002023197,0.00008392181,0.0002860691,0.9275439,0.00005133629,0.001532958,0.000005027299],"study_design_scores_gemma":[0.002145058,0.00006533138,0.5343523,0.003980462,0.000684963,1.240732e-7,0.00009440754,0.0002719719,0.4566454,0.000002655732,0.00118567,0.0005716371],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895597,0.00645268,0.00004294774,0.000404273,0.001096845,0.001380755,0.0009316689,0.0001082564,0.00002284635],"genre_scores_gemma":[0.9977613,0.0005159346,0.0003676631,0.00024762,0.0002298044,0.0007633197,5.394614e-7,0.00009258415,0.00002123011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4708985,"threshold_uncertainty_score":0.9999378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813105992210173,"score_gpt":0.2558592543621484,"score_spread":0.2377281944400467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}