{"id":"W4210470119","doi":"10.1101/2022.01.26.468593","title":"VEGF-C expression in TAMs rewires the metastatic fate of breast cancer cells","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Lymphatic System and Diseases","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Fondazione Regionale per la Ricerca Biomedica; Svenska Sällskapet för Medicinsk Forskning; Cancerfonden","keywords":"Lymphangiogenesis; Metastasis; Breast cancer; Medicine; Cancer research; Lymph node; Lymph; Cancer cell; Cancer; Tumor microenvironment; Circulating tumor cell; Vascular endothelial growth factor C; Angiogenesis; Podoplanin; Primary tumor; Lymphatic system; Pathology; Vascular endothelial growth factor; VEGF receptors; Internal medicine; Vascular endothelial growth factor A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135542,0.0001349863,0.0001157431,0.0001404762,0.0001438489,0.0002592381,0.00007844514,0.0001682509,0.001469004],"category_scores_gemma":[0.0001022161,0.00006140218,0.0001155549,0.00009544485,0.00012648,0.00008730921,0.0001550508,0.0003607867,0.0004700981],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003114176,"about_ca_system_score_gemma":0.0001651364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006182819,"about_ca_topic_score_gemma":0.0005182286,"domain_scores_codex":[0.9999312,0.00001148163,0.000003967288,0.00001245122,0.00001507998,0.00002572415],"domain_scores_gemma":[0.9999555,0.000006064223,0.000007671425,0.000006021457,0.000008095548,0.00001667532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001391004,0.00001692747,0.0004163932,0.00002234076,0.000002383015,0.00006273873,0.00001369433,0.00008569147,0.9972014,0.0003268437,0.0001971771,0.001515243],"study_design_scores_gemma":[0.00002896752,0.0001518122,0.007395056,0.000009561552,0.00001104137,0.0005239848,0.00006076959,0.002517889,0.9809873,0.0002315169,0.008078369,0.000003707623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941269,0.0007754441,0.002036675,0.0001970687,0.00005274976,0.00001569437,0.0002839576,0.00005094795,0.002460513],"genre_scores_gemma":[0.9947528,0.0003046362,0.001161314,0.000063334,0.00001527634,0.00001570146,0.000408537,0.0000195242,0.003258926],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001469004,"threshold_uncertainty_score":0.004914343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01813105992210173,"score_gpt":0.2558592543621484,"score_spread":0.2377281944400467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}