{"id":"W4210482747","doi":"10.1096/fasebj.23.1_supplement.776.5","title":"Regulation of the cardiac phenylethanolamine N‐methyltransferase gene in the spontaneously hypertensive rat","year":2009,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Synthesis and Biological Activity","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"NOSM University; Laurentian University","funders":"","keywords":"Phenylethanolamine; Phenylethanolamine N-methyltransferase; Epinephrine; Internal medicine; Endocrinology; Downregulation and upregulation; Messenger RNA; Gene expression; Methyltransferase; Catecholamine; Biology; Gene; Chemistry; Medicine; Tyrosine hydroxylase; Dopamine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007357966,0.0001024747,0.0001483864,0.00001397804,0.0001364132,0.00001870762,0.0003374391,0.00008313587,0.00001248112],"category_scores_gemma":[0.0001476331,0.00003936345,0.0001859938,0.00009710436,0.0000945977,0.000003191968,0.00002117246,0.0001947399,9.422085e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001010555,"about_ca_system_score_gemma":0.00003119306,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001035892,"about_ca_topic_score_gemma":0.000009770809,"domain_scores_codex":[0.9988852,0.000499584,0.0001826455,0.0001152774,0.0001636427,0.0001536901],"domain_scores_gemma":[0.9994616,0.00007851389,0.00009319448,0.0002779733,0.00006525298,0.00002348355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001184285,0.00005676848,0.0008933177,8.075432e-7,0.00001844666,0.000007146722,0.00007388848,0.00003786069,0.9915661,0.00002323404,0.0001618257,0.007042238],"study_design_scores_gemma":[0.0001768186,0.0002006732,0.09930938,0.000008602497,0.00002720558,0.0003632341,0.0001025328,0.00001266582,0.8987059,0.0002988194,0.0007315218,0.00006263325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960801,0.0006532317,0.0001041679,0.002643542,0.0001294241,0.0001500564,0.0000086974,0.000001628565,0.0002291554],"genre_scores_gemma":[0.9983398,0.0002777419,0.0000509364,0.0009186066,0.0003335799,0.000001982064,0.000005103313,0.000003882342,0.00006834752],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09841606,"threshold_uncertainty_score":0.1605195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164107305718795,"score_gpt":0.2166551498837264,"score_spread":0.2050140768265385,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}