{"id":"W4210487542","doi":"10.31234/osf.io/tcuhd","title":"Partial Least Squares analysis of Alzheimer’s disease biomarkers, modifiable health variables, and cognition in older adults with Mild Cognitive Impairment","year":2020,"lang":"en","type":"preprint","venue":"","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; BioClinica; F. Hoffmann-La Roche; National Institutes of Health; Ohio State University; University of Southern California; Biogen; Novartis Pharmaceuticals Corporation; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; Alzheimer's Disease Neuroimaging Initiative; U.S. Department of Defense; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Episodic memory; Cognition; Psychology; Cohort; Disease; Clinical psychology; Medicine; Neuroscience; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003365098,0.0008589035,0.0007161986,0.0005633426,0.0003584281,0.0005303574,0.0006641422,0.0002416227,0.003029698],"category_scores_gemma":[0.009457109,0.0002515585,0.001203974,0.0007653517,0.0002937546,0.0003165265,0.0007156766,0.0003458033,0.0004657992],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003487834,"about_ca_system_score_gemma":0.001312464,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01256069,"about_ca_topic_score_gemma":0.0140542,"domain_scores_codex":[0.9985493,0.0007907748,0.00006464491,0.0003103373,0.0002068166,0.00007814191],"domain_scores_gemma":[0.9979505,0.0009995567,0.000309852,0.0003427326,0.0003089544,0.00008839309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001005266,0.0003007541,0.8589646,0.000222207,0.003248877,0.0002411669,0.0004222984,0.01255261,0.003946771,0.001233004,0.003655054,0.1142073],"study_design_scores_gemma":[0.00008604347,0.0006927875,0.9097013,0.00002460553,0.0003238498,0.0002751364,0.0002585208,0.08229843,0.001537481,0.002834942,0.001933287,0.00003361371],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9597968,0.0004649627,0.03600619,0.0003502477,0.00003342506,0.0001097726,0.00230166,0.0002547498,0.0006821205],"genre_scores_gemma":[0.9830868,0.0001314803,0.01295551,0.00005863855,0.00001823981,0.0001344546,0.002437672,0.00003221024,0.001144934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01256069,"threshold_uncertainty_score":0.02497518,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.031301247591274,"score_gpt":0.3268061813798935,"score_spread":0.2955049337886195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}