{"id":"W4210498707","doi":"10.1038/s41388-022-02206-z","title":"HSP90 inhibitors induce GPNMB cell-surface expression by modulating lysosomal positioning and sensitize breast cancer cells to glembatumumab vedotin","year":2022,"lang":"en","type":"article","venue":"Oncogene","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; University of Ottawa; McGill University and Génome Québec Innovation Centre; Jewish General Hospital; McGill University","funders":"CIHR Skin Research Training Centre; Canadian Institutes of Health Research; Government of Canada","keywords":"Cancer research; Biology; Breast cancer; Hsp90; Heat shock protein; Cancer; Pharmacology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002675801,0.0001972224,0.0001698663,0.00004797967,0.0004964847,0.0000503899,0.000169428,0.0001153942,0.0001107699],"category_scores_gemma":[0.00001555194,0.0002182274,0.00005039097,0.0001991474,0.00003443705,0.000007633718,0.0008032818,0.0002516398,0.000007571681],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001248883,"about_ca_system_score_gemma":0.0001362508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003446809,"about_ca_topic_score_gemma":0.00001372746,"domain_scores_codex":[0.9981609,0.0001894475,0.0002291679,0.0005857793,0.0003884382,0.0004462958],"domain_scores_gemma":[0.9992805,0.00001641535,0.00006717809,0.0003042108,0.00008562076,0.0002460756],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001097931,0.00006357027,0.0004872098,0.00001999693,0.00001374243,0.00001516218,0.000143577,0.004514752,0.9882162,7.691549e-7,0.004143397,0.002271781],"study_design_scores_gemma":[0.0005251509,0.0002160954,0.0001644788,0.0000282606,0.000007300665,0.00005137279,0.0002332225,0.0004497241,0.9938737,0.000003005414,0.004186068,0.0002616731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971272,0.0007335814,0.000292806,0.000504944,0.000135926,0.0003903671,0.0003398619,0.00002096118,0.0004543105],"genre_scores_gemma":[0.9960663,0.00003827769,0.002057433,0.0002806934,0.0002385273,0.00007953571,0.0001229918,0.00005516074,0.001061078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005657399,"threshold_uncertainty_score":0.8899055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007298903698540376,"score_gpt":0.2576311633710519,"score_spread":0.2503322596725115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}