{"id":"W4210509747","doi":"10.3390/biomedicines10020382","title":"SARS-CoV-2 Dysregulates Neutrophil Degranulation and Reduces Lymphocyte Counts","year":2022,"lang":"en","type":"article","venue":"Biomedicines","topic":"COVID-19 Clinical Research Studies","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Nebraska Medical Center; Canadian Institutes of Health Research; U.S. Department of Veterans Affairs","keywords":"Immunology; Degranulation; Immune system; Elastase; Myeloperoxidase; Lymphocyte; Neutrophil elastase; CD8; Biology; Innate immune system; Neutrophil extracellular traps; Medicine; Inflammation; Receptor; Internal medicine; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002957231,0.00009534738,0.0002231539,0.0001638837,0.0001650724,0.000007678582,0.00006496687,0.00002935012,0.0001261619],"category_scores_gemma":[0.001063614,0.00007225718,0.00003836287,0.0003101726,0.0002649105,0.00002809256,0.0001399528,0.0001008717,0.00002547129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000110671,"about_ca_system_score_gemma":0.0001232309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008161757,"about_ca_topic_score_gemma":0.000001085526,"domain_scores_codex":[0.9989502,0.00003821131,0.0001912911,0.0002234288,0.0004223409,0.0001745526],"domain_scores_gemma":[0.9992055,0.0004593981,0.00004699688,0.0001547303,0.00007041042,0.00006294072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001061272,0.0003893288,0.01779095,0.0007370018,0.0003518917,0.0002725778,0.001124445,0.000009288959,0.6703579,0.0003916542,0.1009464,0.2065673],"study_design_scores_gemma":[0.004508594,0.00138843,0.1129809,0.0001517086,0.0001991817,0.00004516422,0.0003815986,0.002281973,0.01421128,0.001049954,0.8625188,0.0002823998],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815402,0.002581107,0.00001520197,0.01410903,0.0003848159,0.0002764427,0.00001676957,0.00008039969,0.0009960026],"genre_scores_gemma":[0.9959986,0.0007159449,0.0000670349,0.001690763,0.000317995,0.00003249539,0.00002717703,0.00001304151,0.00113691],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7615725,"threshold_uncertainty_score":0.2946562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0562659069991332,"score_gpt":0.3997455657811153,"score_spread":0.3434796587819821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}