{"id":"W4210516353","doi":"10.7554/elife.72452","title":"Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation","year":2021,"lang":"en","type":"article","venue":"eLife","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute on Aging; Medicinska fakulteten, Umeå Universitet; Instituto de Salud Carlos III; National Human Genome Research Institute; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; Medical Research Council; National Institutes of Health; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Hellenic Health Foundation; Junta de Castilla y León; Wereld Kanker Onderzoek Fonds; Xunta de Galicia; Innovative Medicines Initiative; Mutuelle Générale de l'Education Nationale; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; NordForsk; Vetenskapsrådet; Stockholms Läns Landsting; British Heart Foundation; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Damon Runyon Cancer Research Foundation; University of Bristol; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; Ministerstvo Zdravotnictví Ceské Republiky; Engineering and Physical Sciences Research Council; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; European Commission; University of Exeter; Academy of Medical Sciences; Cancerfonden; Canadian Institutes of Health Research; Diabetes UK; Generalitat de Catalunya; Food Standards Agency; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; Wageningen University and Research; Cancer Research UK; University of Cambridge; Moffitt Cancer Center; Pelotonia; Conseil Régional des Pays de la Loire; Génome Québec; Institut Gustave-Roussy; Grantová Agentura České Republiky; Johns Hopkins University; Centre International de Recherche sur le Cancer; World Cancer Research Fund International; Memorial Sloan-Kettering Cancer Center; Division of Cancer Prevention, National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Association Anne de Bretagne Genetique; National Heart, Lung, and Blood Institute; Florida Department of Health; McGill University; Fred Hutchinson Cancer Research Center; Cancer Research Foundation in Northern Sweden; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; University of South Florida; U.S. Department of Health and Human Services","keywords":"Disease; Mendelian inheritance; Mendelian randomization; Adverse effect; Obesity; Medicine; Biology; Physiology; Bioinformatics; Internal medicine; Genetics; Gene; Genetic variants; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001842982,0.0001021015,0.0002368092,0.000019214,0.00005895158,0.000004423928,0.00007168212,0.0001010132,0.000071757],"category_scores_gemma":[0.0005525762,0.00009674328,0.0001113623,0.00007541588,0.00005425698,0.000003013232,0.00005263291,0.00004044497,0.000007023124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000109648,"about_ca_system_score_gemma":0.0001946065,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001176744,"about_ca_topic_score_gemma":0.00003205318,"domain_scores_codex":[0.9990129,0.0002601947,0.0002302809,0.0002434472,0.0001083123,0.0001449029],"domain_scores_gemma":[0.999311,0.00006565337,0.000147152,0.0002076036,0.0001704986,0.00009804051],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001187708,0.00004617422,0.06273302,0.00001286045,0.0002064912,0.000005472835,0.00002277146,0.000933715,0.935136,0.00008146494,0.0005489526,0.000154368],"study_design_scores_gemma":[0.002687034,0.00003432604,0.3300999,0.0000223732,0.0003133937,0.000001372622,0.00003143293,0.0008224064,0.6591841,0.0002244313,0.006389436,0.0001897375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903574,0.00765324,0.001107403,0.0002789042,0.0003013339,0.0001237771,0.0000676,0.000006151951,0.0001041692],"genre_scores_gemma":[0.9963723,0.0004101246,0.001872171,0.00064595,0.0001810588,0.00001061303,0.0002479913,0.000008785503,0.0002510358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2759518,"threshold_uncertainty_score":0.3945076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01778125433827102,"score_gpt":0.2789997149323383,"score_spread":0.2612184605940673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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