{"id":"W4210516353","doi":"10.7554/elife.72452","title":"Disease consequences of higher adiposity uncoupled from its adverse metabolic effects using Mendelian randomisation","year":2021,"lang":"en","type":"article","venue":"eLife","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Center for Advancing Translational Sciences; National Institute of Environmental Health Sciences; National Institute on Aging; Medicinska fakulteten, Umeå Universitet; Instituto de Salud Carlos III; National Human Genome Research Institute; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; Medical Research Council; National Institutes of Health; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Hellenic Health Foundation; Junta de Castilla y León; Wereld Kanker Onderzoek Fonds; Xunta de Galicia; Innovative Medicines Initiative; Mutuelle Générale de l'Education Nationale; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; NordForsk; Vetenskapsrådet; Stockholms Läns Landsting; British Heart Foundation; Bundesministerium für Bildung und Forschung; Ministerio de Economía y Competitividad; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; National Institute of Diabetes and Digestive and Kidney Diseases; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Damon Runyon Cancer Research Foundation; University of Bristol; Chonnam National University; Centres de Recerca de Catalunya; Umeå Universitet; Ministerstvo Zdravotnictví Ceské Republiky; Engineering and Physical Sciences Research Council; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; European Commission; University of Exeter; Academy of Medical Sciences; Cancerfonden; Canadian Institutes of Health Research; Diabetes UK; Generalitat de Catalunya; Food Standards Agency; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; Wageningen University and Research; Cancer Research UK; University of Cambridge; Moffitt Cancer Center; Pelotonia; Conseil Régional des Pays de la Loire; Génome Québec; Institut Gustave-Roussy; Grantová Agentura České Republiky; Johns Hopkins University; Centre International de Recherche sur le Cancer; World Cancer Research Fund International; Memorial Sloan-Kettering Cancer Center; Division of Cancer Prevention, National Cancer Institute; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Association Anne de Bretagne Genetique; National Heart, Lung, and Blood Institute; Florida Department of Health; McGill University; Fred Hutchinson Cancer Research Center; Cancer Research Foundation in Northern Sweden; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; University of South Florida; U.S. Department of Health and Human Services","keywords":"Disease; Mendelian inheritance; Mendelian randomization; Adverse effect; Obesity; Medicine; Biology; Physiology; Bioinformatics; Internal medicine; Genetics; Gene; Genetic variants; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03929459,0.002298285,0.002520913,0.00227038,0.0007273479,0.001171753,0.001860957,0.002009415,0.006064523],"category_scores_gemma":[0.06605425,0.0008251616,0.003700048,0.001927699,0.001496356,0.0008710847,0.001458867,0.001531935,0.0004082729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008830375,"about_ca_system_score_gemma":0.001100195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002840001,"about_ca_topic_score_gemma":0.001484939,"domain_scores_codex":[0.9460041,0.04235684,0.002268625,0.006107671,0.002359862,0.0009029136],"domain_scores_gemma":[0.9585047,0.03106872,0.003036357,0.006211989,0.0008673045,0.00031099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1053665,0.002737558,0.348085,0.006037828,0.06861966,0.01371975,0.003806687,0.06096009,0.03049733,0.09325888,0.01367388,0.2532368],"study_design_scores_gemma":[0.03393628,0.02537723,0.2247178,0.001292827,0.0479077,0.01185835,0.0005867847,0.4922685,0.01691803,0.1098101,0.03450358,0.0008228828],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3439662,0.00207219,0.6326036,0.0008472083,0.0006150255,0.01338186,0.002159466,0.001510622,0.002843875],"genre_scores_gemma":[0.7600798,0.0005496079,0.2152997,0.0005892103,0.0001466093,0.01911493,0.001294276,0.0002186114,0.00270727],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.03929459,"threshold_uncertainty_score":0.2078121,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01778125433827102,"score_gpt":0.2789997149323383,"score_spread":0.2612184605940673,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}