{"id":"W4210520468","doi":"10.1182/bloodadvances.2021006415","title":"Risk profiling of patients with relapsed/refractory diffuse large B-cell lymphoma by measuring circulating tumor DNA","year":2022,"lang":"en","type":"article","venue":"Blood Advances","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Spinal Cord Injury BC; University of British Columbia","funders":"National Cancer Institute; Genentech; F. Hoffmann-La Roche; Leukemia and Lymphoma Society","keywords":"Medicine; Internal medicine; Hazard ratio; International Prognostic Index; Oncology; Diffuse large B-cell lymphoma; Rituximab; Biomarker; Refractory (planetary science); Lymphoma; Bendamustine; Gastroenterology; Confidence interval; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001258812,0.000147111,0.0001595834,0.00002921712,0.0002136237,0.00001131773,0.0001696387,0.00002828422,0.000007783102],"category_scores_gemma":[0.00008654981,0.0001444282,0.00005950327,0.00008333922,0.00003394482,0.000007487376,0.0001769721,0.00008077627,5.214877e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002339746,"about_ca_system_score_gemma":0.00008343692,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001531653,"about_ca_topic_score_gemma":0.00001403349,"domain_scores_codex":[0.998925,0.00005039406,0.0002257985,0.0003306257,0.0002244626,0.0002437033],"domain_scores_gemma":[0.9992617,0.0000334734,0.0003145097,0.0002612878,0.00007069535,0.0000583858],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004355258,0.006934915,0.6370685,0.0001477515,0.0001475748,0.00001237301,0.0001950637,0.001303716,0.3498218,0.0000408294,0.0001691702,0.003722829],"study_design_scores_gemma":[0.02360026,0.00206172,0.01829622,0.00003756634,0.0002251314,0.000007785769,0.0007529116,0.000109321,0.898809,0.00008488787,0.05523015,0.0007850437],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927862,0.005716339,0.0001827284,0.000003314405,0.0001253245,0.0002067711,0.0006620141,0.00001039353,0.0003069213],"genre_scores_gemma":[0.9983999,0.0002574118,0.0008389127,0.00006954702,0.00006339815,0.00005018081,0.0002532676,0.00003415208,0.00003327902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6187722,"threshold_uncertainty_score":0.5889612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003653755520015056,"score_gpt":0.1865165154649354,"score_spread":0.1828627599449204,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}