{"id":"W4210522117","doi":"10.1371/journal.pone.0263005","title":"Cryopreservation and post-thaw characterization of dissociated human islet cells","year":2022,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institutes of Health; University of Alberta; Canada Research Chairs; Juvenile Diabetes Research Foundation United States of America; National Institute of Diabetes and Digestive and Kidney Diseases; Stanford Diabetes Research Center; H. L. Snyder Medical Foundation; Steven and Michele Kirsch Foundation; Silicon Valley Community Foundation","keywords":"Cryopreservation; Islet; Transcriptome; Dimethyl sulfoxide; Cell biology; Cryoprotectant; Biology; Exocytosis; Chemistry; Biochemistry; Gene expression; Embryo; Secretion; Insulin; Gene; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003588847,0.000268413,0.0003250325,0.0003038383,0.0002776429,0.0005452642,0.0003261169,0.0002321329,0.001274436],"category_scores_gemma":[0.0004534424,0.0000931391,0.0002365985,0.0004532613,0.0002353206,0.0003217263,0.0002448474,0.0005759466,0.0005677403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001687874,"about_ca_system_score_gemma":0.0002442645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008541397,"about_ca_topic_score_gemma":0.0009056061,"domain_scores_codex":[0.9998011,0.00001910506,0.00002689781,0.00005632473,0.00007511702,0.00002150618],"domain_scores_gemma":[0.9997731,0.00005066327,0.00002115896,0.0000468737,0.00008819927,0.00002002267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001549818,0.00003475145,0.001660675,0.00005859246,0.0000147446,0.0001673003,0.0001704369,0.0004506239,0.9901006,0.0001056139,0.0001051719,0.006976558],"study_design_scores_gemma":[0.00002226332,0.0003530914,0.03080052,0.00004210228,0.0001043017,0.0004644589,0.0003092285,0.002336017,0.9545037,0.0002778417,0.0107612,0.00002512352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9433797,0.005480492,0.04412828,0.0001669439,0.000165882,0.0003448099,0.002768627,0.0001089134,0.003456336],"genre_scores_gemma":[0.9361581,0.005561391,0.04295717,0.0002775154,0.0000818226,0.0007218063,0.007906999,0.0001859551,0.006149368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001274436,"threshold_uncertainty_score":0.004263401,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03214877522147974,"score_gpt":0.2229629127250517,"score_spread":0.190814137503572,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}