{"id":"W4210533471","doi":"10.1002/jor.25271","title":"Pharmacokinetics and local tissue response to local instillation of vocacapsaicin, a novel capsaicin prodrug, in rat and rabbit osteotomy models","year":2022,"lang":"en","type":"article","venue":"Journal of Orthopaedic Research®","topic":"Anesthesia and Pain Management","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Nuclear Laboratories","funders":"","keywords":"Medicine; Osteotomy; Perioperative; Pharmacokinetics; Systemic administration; Anesthesia; Ropivacaine; Capsaicin; Tolerability; Surgery; In vivo; Pharmacology; Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004181977,0.0004156372,0.0005062688,0.0003899712,0.0001486222,0.0003789255,0.000252068,0.0004133943,0.0007267313],"category_scores_gemma":[0.0006378131,0.0003500071,0.0004063178,0.0002885322,0.0006308468,0.0004468989,0.000115995,0.0007942421,0.0003826565],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00040218,"about_ca_system_score_gemma":0.0004131107,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002012658,"about_ca_topic_score_gemma":0.002730233,"domain_scores_codex":[0.9996595,0.00006847853,0.00002544226,0.00007832159,0.00008034641,0.0000880025],"domain_scores_gemma":[0.9994999,0.0001007293,0.0001840512,0.00007452016,0.0000585497,0.00008218571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004253057,0.0004912774,0.0008577104,0.00007911729,0.00002149988,0.00008994031,0.00009868265,0.0004012677,0.9883686,0.00006160532,0.00008567519,0.005191755],"study_design_scores_gemma":[0.000246169,0.03496251,0.02184024,0.00001244956,0.000146768,0.0005496376,0.0001997974,0.003194008,0.9370803,0.00006595949,0.001666154,0.00003595017],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944927,0.002203601,0.002108314,0.00005920392,0.00003205092,0.000076697,0.0002574604,0.0000699881,0.0007001407],"genre_scores_gemma":[0.9938971,0.002122252,0.001423045,0.00005108976,0.00003237017,0.0001388075,0.0003701345,0.00002102442,0.001944221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002012658,"threshold_uncertainty_score":0.004001915,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05103970401258256,"score_gpt":0.3525756276742421,"score_spread":0.3015359236616595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}